{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T00:52:10Z","timestamp":1771980730538,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T00:00:00Z","timestamp":1659571200000},"content-version":"vor","delay-in-days":215,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2017ZX09304021"],"award-info":[{"award-number":["2017ZX09304021"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. T lymphoblastic lymphoma\/leukemia (T\u2010LBL\/ALL) is an aggressive malignant tumor with 5\u2010year overall survival (OS) rate reached 80% after high\u2010dose chemotherapy. Due to the relatively low incidence of T\u2010LBL\/ALL, only a few risk factors have been identified. The occurrence and prognosis of malignant tumors are closely related to oxidative stress, but the prognostic relationship between T\u2010LBL\/ALL and systematic oxidative stress indexes has not been reported yet. <jats:italic>Methods<\/jats:italic>. A total of 258 T\u2010LBL\/ALL patients were retrospectively analyzed. The relationship between systematic oxidative stress indexes, such as creatinine (CRE), gamma\u2010glutamyl transpeptidase (<jats:italic>\u03b3<\/jats:italic>\u2010GGT), albumin (ALB), alkaline phosphatase (ALP), fibrinogen (FBG), C\u2010reactive protein (CRP) and total bilirubin (TBIL), and survival of T\u2010LBL\/ALL patients, was analyzed. The weight of indexes was used to calculate the patients' oxidative stress risk score. The independent prognostic value of oxidative stress risk grouping (OSRG) was analyzed. <jats:italic>Results<\/jats:italic>. Higher CRE, CRP, and lower ALB were associated with poorer OS in T\u2010LBL\/ALL patients. The OSRG established by CRE, ALB, and CRP was an independent prognostic factor for OS of T\u2010LBL\/ALL patients. Patients in the high\u2010risk group were more likely to be patients older than 14 years old and patients with superior vena cava obstruction syndrome (SVCS), pleural effusion, pericardial effusion, and mediastinal mass. <jats:italic>Conclusion<\/jats:italic>. For OS in T\u2010LBL\/ALL patients, OSRG was observed as an independent prognostic factor, which provided a new idea for accurate prognostic prediction.<\/jats:p>","DOI":"10.1155\/2022\/2679154","type":"journal-article","created":{"date-parts":[[2022,8,4]],"date-time":"2022-08-04T22:50:06Z","timestamp":1659653406000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Systematic Oxidative Stress Indexes Associated with the Prognosis in Patients with T Lymphoblastic Lymphoma\/Leukemia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2556-7834","authenticated-orcid":false,"given":"Liqin","family":"Ping","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Gao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanxia","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Bai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4623-0536","authenticated-orcid":false,"given":"Huiqiang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,4]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.14017"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.2015.139162"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.25957"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4002"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6545728"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0160686"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2007.05.004"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2022.108109"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.17179\/excli2015-245"},{"key":"e_1_2_10_10_2","article-title":"Exploring early detection of frailty syndrome in older adults: evaluation of oxi-immune markers, clinical parameters and modifiable risk factors","volume":"10","author":"Teixeira-Gomes A.","year":"2021","journal-title":"Antioxidants (Basel, Switzerland)"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102152"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2018.2306"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2021.1999489"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7087921"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2004.07.045"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.114.303785"},{"key":"e_1_2_10_17_2","article-title":"A leaky blood-brain barrier to fibrinogen contributes to oxidative damage in Alzheimer\u2019s disease","volume":"11","author":"McLarnon J. 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