{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:10:22Z","timestamp":1792087822503,"version":"4.4.0"},"reference-count":80,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T00:00:00Z","timestamp":1646179200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Guangdong Provincial Science and Technology Innovation Strategy","award":["2021B1111610007"],"award-info":[{"award-number":["2021B1111610007"]}]},{"name":"Guangdong Provincial Science and Technology Innovation Strategy","award":["2021A1515011545"],"award-info":[{"award-number":["2021A1515011545"]}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021B1111610007"],"award-info":[{"award-number":["2021B1111610007"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011545"],"award-info":[{"award-number":["2021A1515011545"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2022,3,2]]},"abstract":"<jats:p>Background. Knee osteoarthritis (KOA) is a high incidence chronic joint disease that seriously affects patients\u2019 quality of life, and current treatment methods have limited efficacy. Self-management may be an effective strategy for KOA, and clinicians have been showing increased interest recently. However, the effectiveness of self-management for KOA remains controversial. Purpose. This study aims to systematically evaluate the effectiveness of self-management for KOA. Methods. We screened articles published in MEDLINE, Cochrane Library, EMBASE, and Web of Science until September 17, 2021. The main outcomes included pain, knee function, stiffness, WOMAC (total), physical function, arthritis self-efficacy (ASE-pain), arthritis self-efficacy (ASE-other symptoms), mental health, and quality of life. Results. Thirteen randomized controlled trials (RCTs) were finally included (n\u2009=\u20091610). Meta-analysis showed differences in pain, knee function, stiffness, ASE-pain, ASE-other symptoms, mental health, and quality of life between the self-management and control groups. Of the nine outcomes evaluated, four were highly heterogeneous, and the quality of evidence ranged from very low to moderate. Conclusion. The meta-analysis results showed that self-management might help improve the pain, knee function, stiffness, ASE, mental health, and quality of life in patients with KOA. However, it has no significant effect on WOMAC (total) and physical function. Considering that this study has some limitations, we cannot draw clear conclusions based on the results of this study. Nevertheless, we offer much needed insight and encourage more rigorously designed and implemented RCTs in the future to substantiate our conclusions.<\/jats:p>","DOI":"10.1155\/2022\/2681240","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T12:05:15Z","timestamp":1646222715000},"page":"1-19","source":"Crossref","is-referenced-by-count":35,"title":["Self-Management for Knee Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0564-0643","authenticated-orcid":true,"given":"Zugui","family":"Wu","sequence":"first","affiliation":[{"name":"The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2315-5569","authenticated-orcid":true,"given":"Rui","family":"Zhou","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4610-8610","authenticated-orcid":true,"given":"Yue","family":"Zhu","sequence":"additional","affiliation":[{"name":"Baishui Health Center, Qujing 655335, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziquan","family":"Zeng","sequence":"additional","affiliation":[{"name":"The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China"},{"name":"Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510405, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Ye","sequence":"additional","affiliation":[{"name":"The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenbang","family":"Wang","sequence":"additional","affiliation":[{"name":"Qujing Hospital of Traditional Chinese Medicine, Qujing 655000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8887-8429","authenticated-orcid":true,"given":"Wengang","family":"Liu","sequence":"additional","affiliation":[{"name":"The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China"},{"name":"Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510405, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6093-7183","authenticated-orcid":true,"given":"Xuemeng","family":"Xu","sequence":"additional","affiliation":[{"name":"The Fifth Clinical Medical College, Guangzhou University of Chinese Medicine, Guangzhou 510405, China"},{"name":"Guangdong Second Traditional Chinese Medicine Hospital, Guangzhou 510405, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22897"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204763"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s12178-011-9084-9"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1136\/ard.60.2.91"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.2340\/16501977-2272"},{"issue":"8","key":"8","first-page":"S230","article-title":"The economic burden of osteoarthritis","volume":"15","author":"R. 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