{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:20:24Z","timestamp":1767165624353,"version":"build-2238731810"},"reference-count":49,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T00:00:00Z","timestamp":1663545600000},"content-version":"vor","delay-in-days":261,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Technological Innovation and Demonstration of Social Undertakings Project","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Technological Innovation and Demonstration of Social Undertakings Project","award":["BE2018673"],"award-info":[{"award-number":["BE2018673"]}]},{"name":"Science Foundation of the Jiangsu Province","award":["2022"],"award-info":[{"award-number":["2022"]}]},{"name":"Science Foundation of the Jiangsu Province","award":["BE2018673"],"award-info":[{"award-number":["BE2018673"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    <jats:italic>Background<\/jats:italic>\n                    . The tumor immune microenvironment (TME) is associated with cancer progression and immune escape. Although KLHDC8A has been reported in glioma\n                    <jats:italic>in vitro<\/jats:italic>\n                    , the expression and clinical significance of this gene in clinical samples are unknown.\n                    <jats:italic>Methods<\/jats:italic>\n                    . The Cancer Genome Atlas and Chinese Glioma Genome Atlas databases were used to evaluate the mRNA expression level of\n                    <jats:italic>KLHDC8A<\/jats:italic>\n                    and its significance in the glioma TME. Tissue microarray\u2010based multiple immunohistochemical staining was conducted to determine KLHDC8A protein levels and characterize the immune signature of tumor\u2010infiltrating immune cells in gliomas.\n                    <jats:italic>Results<\/jats:italic>\n                    . Tumor cells and tumor\u2010associated macrophages expressed KLHDC8A. The expression of KLHDC8A was higher in glioma tissues than in normal brain tissues and was associated with patient clinical characteristics. Gliomas exhibited a high abundance of macrophages, neutrophils, regulatory T cells, and the immune checkpoint PD\u2010L1, as well as high KLHDC8A expression. Cox regression analysis showed that KLHDC8A+CD68+ macrophages and KLHDC8A predicted unfavorable survival in patients with glioma. Finally, protein\u2010protein interaction network analysis showed that the KLHDC8A expression was associated with hypoxia and oxidative stress.\n                    <jats:italic>Conclusions<\/jats:italic>\n                    . KLHDC8A is a potential marker for the clinical diagnosis of glioma. The immune characteristics of macrophages play a crucial role in predicting patients with glioma, providing a new avenue for targeted glioma therapy.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2694377","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T00:50:05Z","timestamp":1663635005000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["[Retracted] KLHDC8A Expression in Association with Macrophage Infiltration and Oxidative Stress Predicts Unfavorable Prognosis for 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