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In addition another two thiosemicarbazones (3\u2010formylpyridine <jats:italic>N<\/jats:italic><jats:sup>4<\/jats:sup>\u2010allylthiosemicarbazone (<jats:italic>HL<\/jats:italic><jats:sup>a<\/jats:sup>) and 4\u2010formylpyridine <jats:italic>N<\/jats:italic><jats:sup>4<\/jats:sup>\u2010allylthiosemicarbazone (<jats:italic>HL<\/jats:italic><jats:sup>b<\/jats:sup>)) have been obtained. The synthesized thiosemicarbazones have been studied using <jats:sup>1<\/jats:sup>H and <jats:sup>13<\/jats:sup>C NMR spectroscopy, IR spectroscopy, and X\u2010ray diffraction analysis. The composition and structure of complexes were studied using elemental analysis, IR and UV\u2010Vis spectroscopies, molar conductivity, and magnetic susceptibility measurements. Single crystal X\u2010ray diffraction analysis elucidated the structure of thiosemicarbazones <jats:italic>HL<\/jats:italic>, <jats:italic>HL<\/jats:italic><jats:sup>a<\/jats:sup>, and <jats:italic>HL<\/jats:italic><jats:sup>b<\/jats:sup>, as well as complexes <jats:bold>4<\/jats:bold> and <jats:bold>5<\/jats:bold>. The antiproliferative properties of these compounds toward a series of cancer cell lines (HL\u201060, HeLa, BxPC\u20103, RD) and a normal cell line (MDCK) have been investigated. The nickel complex shows high selectivity (SI\u2009&gt;\u20091000) toward HL\u201060 cell line and is the least toxic. The zinc complex shows the highest selectivity toward RD cell line (SI\u2009=\u2009640). The copper complexes (<jats:bold>2<\/jats:bold>\u2013<jats:bold>4<\/jats:bold>) are the most active molecular inhibitors of proliferation of cancer cells, but exhibit not such a high selectivity and are significantly more toxic. Zinc and copper complexes manifest high antibacterial activity. It was found that calculated at B3LYP level of theory different reactivity descriptors of studied compounds strongly correlate with their biological activity.<\/jats:p>","DOI":"10.1155\/2022\/2705332","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T20:05:48Z","timestamp":1653509148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Synthesis, Structure, and Biologic Activity of Some Copper, Nickel, Cobalt, and Zinc Complexes with 2\u2010Formylpyridine <i>N<\/i><sup>4<\/sup>\u2010Allylthiosemicarbazone"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8153-2153","authenticated-orcid":false,"given":"Vasilii","family":"Graur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-2871","authenticated-orcid":false,"given":"Yurii","family":"Chumakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-892X","authenticated-orcid":false,"given":"Olga","family":"Garbuz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3339-0239","authenticated-orcid":false,"given":"Christelle","family":"Hureau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1732-3116","authenticated-orcid":false,"given":"Victor","family":"Tsapkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2010-7959","authenticated-orcid":false,"given":"Aurelian","family":"Gulea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules18088812"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.7.10"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.10.034"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2021.103581"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1039\/b209042b"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/aoc.6172"},{"key":"e_1_2_8_7_2","volume-title":"WHO Report on Cancer: Setting Priorities, Investing Wisely and Providing Care for All","year":"2020"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2017.12.040"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105464"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1529"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.12508"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ica.2021.120671"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0162-0134(01)00321-x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/14756360701743002"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21050674"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600540438"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600541127"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0008-6215(00)83057-8"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/1692540"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11094-019-01968-3"},{"key":"e_1_2_8_21_2","article-title":"Synthesis, characterization and trypanocidal activity of 1,3,4- thiadiazolines derivatives","volume":"5","author":"Fatondji H. 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