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In this study, male Wistar rats were treated via the oral route with rutin and quercetin (50\u2009mg\/kg) either alone or in combination every other day for five weeks concomitant with receiving intraperitoneal DXR (2\u2009mg\/kg) two times a week for five successive weeks. Quercetin, rutin, and their combination significantly improved the deteriorated serum AST, ALT, and ALP activities and total bilirubin level, as well as albumin, AFP, and CA 19.9 levels in DXR\u2010injected rats. Treatments of the DXR\u2010injected group with quercetin and rutin prevented the elevation in liver lipid peroxidation and the reduction in superoxide dismutase, glutathione\u2010S\u2010transferase and glutathione peroxidase activities, and glutathione content. Treatments with quercetin and rutin significantly repressed the elevated expression of liver p53 and TNF\u2010<jats:italic>\u03b1<\/jats:italic> and enhanced Nrf2 expression. Furthermore, the treatments significantly reduced DXR\u2010induced liver histological changes. In conclusion, rutin and quercetin either alone or in combination may have potential preventive effects against DXR\u2010induced hepatotoxicity through inhibiting oxidative stress, inflammation, and apoptosis as well as modulating the Nrf2 expression.<\/jats:p>","DOI":"10.1155\/2022\/2710607","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T18:35:14Z","timestamp":1658946914000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Rutin and Quercetin Counter Doxorubicin\u2010Induced Liver Toxicity in Wistar Rats <i>via<\/i> Their Modulatory Effects on Inflammation, Oxidative Stress, Apoptosis, and Nrf2"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3781-9709","authenticated-orcid":false,"given":"Osama M.","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-6024","authenticated-orcid":false,"given":"Mohammed H.","family":"Elkomy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8380-8336","authenticated-orcid":false,"given":"Hanaa I.","family":"Fahim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9425-8288","authenticated-orcid":false,"given":"Mohamed B.","family":"Ashour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5923-1466","authenticated-orcid":false,"given":"Ibrahim A.","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9411-3609","authenticated-orcid":false,"given":"Badrah S.","family":"Alghamdi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5772-6326","authenticated-orcid":false,"given":"Heba Uallah R.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-0933","authenticated-orcid":false,"given":"Noha A.","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-418-0_7"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22071106"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2011.03.002"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2010.02.002"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2009.10.042"},{"key":"e_1_2_10_6_2","first-page":"215","article-title":"Cardioprotective effects of Hesperetin against doxorubicin-induced oxidative stress and DNA damage in rat","volume":"11","author":"Trivedi P. 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