{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T01:18:56Z","timestamp":1768958336488,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31471091"],"award-info":[{"award-number":["31471091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2022,5,2]]},"abstract":"<jats:p>Myocardial hypertrophy is a pathological feature of many heart diseases. This is a complex process involving all types of cells in the heart and interactions with circulating cells. This study is aimed at identifying the differentially expressed proteins (DEPs) in myocardial hypertrophy rats induced by isoprenaline (ISO) and treated with novel peptide Athycaltide-1 (ATH-1) and exploring the mechanism of its improvement. ITRAQ was performed to compare the three different heart states in control group, ISO group, and ATH-1 group. Pairwise comparison showed that there were 121 DEPs in ISO\/control (96 upregulated and 25 downregulated), 47 DEPs in ATH-1\/ISO (27 upregulated and 20 downregulated), and 116 DEPs in ATH-1\/control (77 upregulated and 39 downregulated). Protein network analysis was then performed using the STRING software. Functional analysis revealed that Hspa1 protein, oxidative stress, and MAPK signaling pathway were significantly involved in the occurrence and development of myocardial hypertrophy, which was further validated by vivo model. It is proved that ATH-1 can reduce the expression of Hspa1 protein and the level of oxidative stress in hypertrophic myocardium and further inhibit the phosphorylation of p38 MAPK, JNK, and ERK1\/2.<\/jats:p>","DOI":"10.1155\/2022\/2715084","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T17:06:34Z","timestamp":1651511194000},"page":"1-13","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Therapeutic Targets of A Novel Peptide Athycaltide-1 in the Treatment of Isoproterenol-Induced Pathological Myocardial Hypertrophy"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xi","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuxiang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"},{"name":"Department of Cardiology, Shengjing Hospital, China Medical University, Shenyang 110020, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ze","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"},{"name":"Department of Clinical Pharmacy, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou 121001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0301-1827","authenticated-orcid":true,"given":"Liying","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.65.092101.142243"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(85)80528-3"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.008788"},{"issue":"5","key":"4","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.2741\/e484","article-title":"Beta-adrenoceptor signaling pathways mediate cardiac pathological remodeling","volume":"4","author":"Y. 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