{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:45:15Z","timestamp":1740159915606,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["21K16174","S2017-8"],"award-info":[{"award-number":["21K16174","S2017-8"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004043","name":"Kanazawa Medical University","doi-asserted-by":"publisher","award":["21K16174","S2017-8"],"award-info":[{"award-number":["21K16174","S2017-8"]}],"id":[{"id":"10.13039\/501100004043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Nephrology"],"published-print":{"date-parts":[[2022,8,9]]},"abstract":"<jats:p>This retrospective exploratory study aimed to identify early clinical indicators of kidney prognosis in primary nephrotic syndrome (NS). Univariate Cox proportional hazards regression analysis identified clinical parameters in the 2-month period after initiating immunosuppressive therapy (IST); it predicted 40% reduction in the estimated glomerular filtration rate (eGFR) in 36 patients with primary NS. Time-dependent receiver operating characteristic curve analysis was used to evaluate the performance of the predictors for the cumulative incidence of 40% reduction in the eGFR up to 8 years after initiating IST. The mean follow-up period was 71.9 months. The eGFR was reduced by 40% in four patients. Significant predictors for time to 40% reduction in the eGFR were as follows: an increase in the serum soluble urokinase plasminogen activator receptor (s-suPAR) 2 months after initiating IST (\u0394s-suPAR (2M); hazard ratio (HR) for every 500\u2009pg\/mL increase: 1.36, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.006<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), s-suPAR at 2 months after initiating IST (s-suPAR (2M); HR for every 500\u2009pg\/mL increase: 1.13, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.015<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>), urinary protein-to-creatinine ratio (u-PCR) (u-PCR (2M); HR for every 1.0\u2009g\/gCr increase: 2.94, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.003<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>), and urinary liver-type fatty acid-binding protein (u-L-FABP) (u-L-FABP (2M); HR for every 1.0\u2009\u03bcg\/gCr increase: 1.14, <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.006<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). All four factors exhibited high predictive accuracy for cumulative incidence of 40% reduction in the eGFR up to 8 years after initiating IST, with areas under the receiver operating characteristic curve of 0.92 for \u0394s-suPAR (2M), 0.87 for s-suPAR (2M), 0.93 for u-PCR (2M), and 0.93 for u-L-FABP (2M). These findings suggest that \u0394s-suPAR (2M), s-suPAR (2M), u-PCR (2M), and u-L-FABP (2M) could be useful indicators of initial therapeutic response for predicting kidney prognosis in primary NS.<\/jats:p>","DOI":"10.1155\/2022\/2718810","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T14:47:03Z","timestamp":1660056423000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Early, Noninvasive Clinical Indicators of Kidney Prognosis in Primary Nephrotic Syndrome: A Retrospective Exploratory Study"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7392-8753","authenticated-orcid":true,"given":"Keiji","family":"Fujimoto","sequence":"first","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takatoshi","family":"Haraguchi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sho","family":"Kumano","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keita","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiko","family":"Miyatake","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanae","family":"Nomura","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Mukai","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuaki","family":"Okino","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norifumi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroki","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Iida","sequence":"additional","affiliation":[{"name":"Department of Mathematics, Kanazawa Medical University, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Furuichi","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Kanazawa Medical University School of Medicine, Ishikawa 920-0293, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"3","key":"1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/ki.1997.127","article-title":"Validation of a predictive model of idiopathic membranous nephropathy: its clinical and research implications","volume":"51","author":"D. 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