{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T02:54:12Z","timestamp":1764557652886,"version":"3.44.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T00:00:00Z","timestamp":1659484800000},"content-version":"vor","delay-in-days":214,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100018479","name":"Guangzhou Institute of Pediatrics, Guangzhou Women and Childrens Medical Center","doi-asserted-by":"publisher","award":["YIP-2018-027","IP-2019-018","IP-2019-020"],"award-info":[{"award-number":["YIP-2018-027","IP-2019-018","IP-2019-020"]}],"id":[{"id":"10.13039\/100018479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["International Journal of Clinical Practice"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Between 10 and 20% of Kawasaki disease (KD) patients are resistant to treatment with initial intravenous immunoglobulin (IVIG) and have a high risk of developing coronary artery lesions. Some studies have been conducted to identify predictive factors. However, the results are controversial. This study aims to identify the risk factors for IVIG\u2010resistant KD patients in a Chinese population. <jats:italic>Methods<\/jats:italic>. We performed a retrospective analysis of medical records of consecutive KD patients from two medical centers in South China from January 2015 to December 2017. A total of 1281 KD patients were eligible for inclusion in this study and maintained follow\u2010up for over 12 months. The KD patients were divided into two groups based on IVIG response. Clinical characteristics and laboratory variables were compared between the two groups. Multivariate logistic regression analysis was performed to identify the risk factors of IVIG resistance in KD patients. <jats:italic>Results<\/jats:italic>. Of the 1281 KD patients, 141 (11.0%) cases who were IVIG resistant to adjunctive therapies for primary treatment were classified as group 1. The remaining patients were in group 2 (<jats:italic>n<\/jats:italic>\u2009=\u20091140), classified as the control group. There was a signi\ufb01cant difference in male to female ratio and the length of hospital stay between the two groups (<jats:italic>P<\/jats:italic> &lt; 0.05). Group 1 had a higher white blood cell count (<jats:italic>P<\/jats:italic> = 0.01) and C\u2010reactive protein level (<jats:italic>P<\/jats:italic> &lt; 0.01) before IVIG treatment than in group 2. Group 1 had a significantly higher white blood cell count and percentage of neutrophils after the IVIG infusion than in group 2 (<jats:italic>P<\/jats:italic> &lt; 0.001). In addition, the mean values of C\u2010reactive protein level and neutrophil percentage before and after treatment difference comparison were significantly different. Multivariate analysis showed that patients presenting with coronary artery lesions in the acute phase and a C\u2010reactive protein level &gt;100\u2009mg\/L at diagnosis were associated with IVIG resistance in KD. During the 12\u2010month follow\u2010up period, group 1 had an obviously higher incidence of coronary artery lesions than group 2, and the difference between the groups was statistically significant (<jats:italic>P<\/jats:italic> &lt; 0.001). <jats:italic>Conclusions<\/jats:italic>. Patients presenting with coronary artery lesions in the acute phase and elevated C\u2010reactive protein levels before IVIG treatment might be a useful and important value for predicting IVIG resistance in KD. Risk assessment based on coronary artery lesions and C\u2010reactive protein levels prior to the treatment may improve the outcome of IVIG resistance.<\/jats:p>","DOI":"10.1155\/2022\/2726686","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T13:35:10Z","timestamp":1659533710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Predictors for Intravenous Immunoglobulin Resistance in Patients with Kawasaki 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