{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T22:31:07Z","timestamp":1774305067456,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T00:00:00Z","timestamp":1654646400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015507","name":"Shandong First Medical University","doi-asserted-by":"publisher","award":["2019QL017"],"award-info":[{"award-number":["2019QL017"]}],"id":[{"id":"10.13039\/501100015507","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,6,8]]},"abstract":"<jats:p>Background. The increased red cell distribution width (RDW) is related to a higher risk for cardiovascular disease (CVD). However, it is yet unclear whether the dynamic change of RDW is associated with the major adverse cardiovascular events (MACEs) for individual with CVD. Methods and Results. A cohort study was conducted among 228 patients who had unstable angina (UA) and underwent PCI. RDW was measured preceding PCI and re-measured on the 16th week after PCI. The change of RDW values was defined as \u0394RDW. The patients were divided into 3 groups in accordance with \u0394RDW: improved, stable, and worsened RDW groups. The patients were followed up for 6 years, and MACE episodes were recorded. The survival analysis showed that the incidence of MACEs in stable RDW group was significantly lower than that in improved and worsened RDW groups. By the COX model, the risk of the occurrence of cardiovascular events in improved RDW group was 1.661 times higher than the risk in stable RDW group (HR\u2009=1.661, 95% CI: 1.583-2.880, <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>) and the same situation was 3.307 times higher in worsened RDW group (HR\u2009=3.307, 95% CI: 1.830-5.041, <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusion. The measurement of \u0394RDW has potential to predict the MACEs in UA patients underwent PCI. The dynamic changes in RDW are associated with the outcome of CVD.<\/jats:p>","DOI":"10.1155\/2022\/2735717","type":"journal-article","created":{"date-parts":[[2022,6,8]],"date-time":"2022-06-08T14:20:06Z","timestamp":1654698006000},"page":"1-7","source":"Crossref","is-referenced-by-count":8,"title":["Dynamic Changes in Red Cell Distribution Width Can Predict Major Adverse Cardiovascular Events after PCI in Patients with Unstable Angina Pectoris: A Retrospective Cohort Study"],"prefix":"10.1155","volume":"2022","author":[{"given":"Qiang","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dekai","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Fourth People\u2019s Hospital of Jinan, Jinan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Qin","sequence":"additional","affiliation":[{"name":"Department of Radiology, the Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3385-3734","authenticated-orcid":true,"given":"Yuanmin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, The Second Affiliated Hospital, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00551-6"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190925163827"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.02.067"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32834e4f5c"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrtlng.2019.10.008"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0049"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18040724"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-015-2039-5"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S339945"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1186\/s12874-017-0436-z"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-019-1082-8"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2016.06.35"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz156"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2009.05.005"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.3109\/10408363.2014.992064"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23982"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872016000500012"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.727545"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2017.01.045"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305028"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.20524\/aog.2020.0486"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v10.i2.6"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.3233\/CH-2012-1573"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/bs.vh.2017.02.001"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01043"}],"container-title":["Disease 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