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However, treatments of T2DM are mainly based on Western medicine, whose severe side effects make traditional Chinese medicine (TCM) therapy more appealing to patients and clinicians. The overall clinical evidence for different TCM therapies in the treatment of T2DM is still unclear. This study aimed to adopt the evidence-mapping method and integrate the evidence from various researches on this topic, to depict the whole picture of TCM therapies for T2DM. This review included searches of PubMed, Embase, Web of Science, and three major Chinese literature databases (CNKI, VIP, and Wanfang) from inception to November 18, 2021. Two independent reviewers screened the literature, extracted information, and evaluated the quality of all included studies. A systematic review was subsequently performed. In total, 47 studies were reviewed, of which 46 studies (97.9%) were from China and 1 (2.1%) was from Canada. The evidence map was conducted according to different TCM therapies, including herbs or herbal extracts, compounds, powders, decoctions, pills, external treatment, basic theories and treatment principles of TCM, proprietary Chinese medicines, and unspecified TCM integrated therapies. According to the AMSTAR-2 scoring results, 4 papers were rated as high quality, 11 were low quality, and 32 were very low quality. Outcome indicators mainly focused on FBG, HbA1c, 2-h PBG, TC, TG, LDL-C, etc. The results showed that different types of TCM treatment had different improvement effects on the outcome indicators of T2DM. More consistent benefits were observed in the improvement of FBG, HbA1c, and 2-h PBG with treatment regimens based on basic theories and treatment principles of TCM, decoctions and pills, and unspecified TCM integrated therapies. Among herbs, ginger and Coptis root showed more improvement in all outcomes. Compounds, powders, and external treatment showed relatively consistent beneficial effects on the improvement of FBG. No serious adverse events were reported. Overall, the current evidence map provided an intuitive overview of the beneficial effects of TCM therapies in the treatment of type 2 diabetes. This study can be used as a reference for the clinical application of traditional Chinese medicine in T2DM, but due to the low-quality level of the included studies, it should be treated with caution in clinical practices.<\/jats:p>","DOI":"10.1155\/2022\/2755332","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T22:05:09Z","timestamp":1658268309000},"page":"1-18","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Application of Traditional Chinese Medicine Therapy for Type 2 Diabetes Mellitus: An Evidence Map"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7535-088X","authenticated-orcid":true,"given":"Ying","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Medical Administration, West China Hospital, Sichuan University, Chengdu 610000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-9741","authenticated-orcid":true,"given":"Zelei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Head and Neck Oncology, Cancer Center, West China Clinical School of Medicine, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9181-6173","authenticated-orcid":true,"given":"Qin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Evidence-Based Medicine and Clinical Epidemiology, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-2655","authenticated-orcid":true,"given":"Ying","family":"He","sequence":"additional","affiliation":[{"name":"Department of Integrated Traditional and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1022-502X","authenticated-orcid":true,"given":"Yalan","family":"Peng","sequence":"additional","affiliation":[{"name":"Hospital Infection Control Department, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3035-9914","authenticated-orcid":true,"given":"Miaomiao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Practice and National Clinical Research Center for Geriatrics, International Medical Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3665-237X","authenticated-orcid":true,"given":"Haiqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of General Practice and National Clinical Research Center for Geriatrics, International Medical Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8097-1058","authenticated-orcid":true,"given":"Long","family":"Ma","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou 730000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-3815","authenticated-orcid":true,"given":"Yonggang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Periodical Press, West China Hospital, Sichuan University, Chengdu 610041, China"},{"name":"Chinese Evidence-Based Medicine Center, West China Hospital, Sichuan University, Chengdu 610041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3253-2565","authenticated-orcid":true,"given":"Nian","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Administration, West China Hospital, Sichuan University, Chengdu 610000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1016\/s0254-6272(16)30074-7"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa0908292"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.168118"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m997"},{"issue":"6","key":"5","first-page":"591","article-title":"Complementary and alternative med-icine for the treatment of type 2 diabetes","volume":"55","author":"R. 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