{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T03:59:17Z","timestamp":1787803157917,"version":"build-2784847793"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T00:00:00Z","timestamp":1660003200000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Many studies have found that circRNA hsa_0002360 (circ0002360) plays an important role in cancer onset and progression. However, its role in gastric cancer (GC) remains uncertain. Circ0002360 was found to be upregulated in GC cells using QRT\u2010PCR. Furthermore, miR\u2010629\u20103p, a target miRNA of circ0002360, was the most suppressed miRNA following circ0002360 overexpression. RNA immunoprecipitation (RIP), dual\u2010luciferase reporter analyses, clone formation, transwell, DCFH\u2010DA, and ELISA assays demonstrated that circ0002360\u2010targeted miR\u2010629\u20103p promotes cell proliferation and migration while inhibiting oxidative stress. GC\u2010related mRNA microarrays from the GEO and TCGA databases, including GSE103236, GSE79973, GSE33429, GSE22804, GSE84437, and TCGA\u2010STAD datasets, were used to find hub biomarkers between normal and gastric cancer samples. WGCNA and uni\u2010Cox analysis were used to identify 27 survival\u2010related risk genes, which were then used to build a risk model for prognosis prediction. Following that, all patients from the GSE84437 and TCGA\u2010STAD datasets with 27 survival\u2010related genes and enough data on survival status and time were randomly assigned to train (<jats:italic>n<\/jats:italic> = 433) and test (<jats:italic>n<\/jats:italic> = 375) cohorts. Furthermore, ROC and Kaplan\u2010Meier (KM) analyses were used to validate the risk model for both cohorts. randomForest analysis indicated that PDLIM4 was the target gene of miR\u2010629\u20103p, whose level was increased by circ0002360 but reversed by miR\u2010629\u20103p mimics. Finally, this study confirmed that circ0002360 sponged miR\u2010629\u20103p and then upregulated PDLIM4 expression. As a result, circ0002360 may be a useful marker for predicting GC prognosis and an anti\u2010GC treatment target.<\/jats:p>","DOI":"10.1155\/2022\/2775433","type":"journal-article","created":{"date-parts":[[2022,8,9]],"date-time":"2022-08-09T23:20:25Z","timestamp":1660087225000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["[Retracted] Circular RNA hsa_circ_0002360 Promotes Proliferation and Invasion and Inhibits Oxidative Stress in Gastric Cancer by Sponging miR\u2010629\u20103p and Regulating the PDLIM4 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