{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:50:42Z","timestamp":1787017842654,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T00:00:00Z","timestamp":1655337600000},"content-version":"vor","delay-in-days":166,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Diabetic cardiomyopathy (DCM) pathogenesis is multifarious, and there are insufficient therapeutic options to treat DCM. The present research explored the effects of Citrus grandis peel ethanolic extract (CGPE) in alloxan\u2010induced DCM in rats. Diabetes was triggered by intraperitoneal (i.p.) injection of alloxan (150\u2009mg\/kg) in Wistar rats (200\u2010250\u2009g). CGPE (100, 200, and 400\u2009mg\/kg) or glibenclamide (Glib, 10\u2009mg\/kg) were administered orally for 2 weeks. After the treatment schedule, prooxidants (thiobarbituric acid reactive substances), antioxidants (glutathione, catalase, and superoxide dismutase), and inflammatory markers (tumor necrosis factor\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) were determined in cardiac tissues. Biomarkers of cell death, viz., lactate dehydrogenase (LDH), creatine kinase MB (CK\u2010MB) activity, glucose levels, total cholesterol (TC), and high\u2010density lipoproteins (HDL), were assessed in the blood. Rats administered with alloxan showed a consistent increase in blood glucose level (days 7 and 14) that was lowered considerably (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) by CGPE or Glib. Alloxan\u2010induced increase in LDH, CK\u2010MB, TC, and decline in HDL was attenuated (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) in rats that were treated with CGPE or Glib. Alloxan significantly (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) elevated oxidative stress, inflammation, and reduced antioxidants in the cardiac tissue of rats, and these pathogenic abnormalities were ameliorated (\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) by CGPE. Histopathological studies showed a decrease in morphological disruptions by alloxan in CGPE\u2010treated rats. CGPE (400\u2009mg\/kg) significantly ameliorated biochemical parameters in comparison to the lower doses against alloxan cardiotoxicity. Citrus grandis peel extract can be an alternative in the management of DCM.\n                  <\/jats:p>","DOI":"10.1155\/2022\/2807337","type":"journal-article","created":{"date-parts":[[2022,6,16]],"date-time":"2022-06-16T19:35:08Z","timestamp":1655408108000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Cardioprotection by Citrus grandis (L.) 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