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However, spatial heterogeneity has not been fully considered in the existing evaluation models or methods for regional ecological efficiency (REE), and the corresponding decisions on sustainable development are not the optimal solutions. To solve the problems, this paper explores the evaluation of REE and intelligent decision support for sustainable development by analyzing environmental big data. Firstly, the spatiotemporal evolution of REE was examined based on environmental big data to clarify the spatial layout of REE and the sources of the spatial differences. Next, a multiobjective optimal decision-making model was established for the sustainable development of a regional ecosystem, and the solving method was presented for the model. 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