{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:52:29Z","timestamp":1767167549811,"version":"build-2238731810"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T00:00:00Z","timestamp":1663113600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Application of Electronic Ketone Meter in Children with Type 1 Diabetic Ketoacidosis","award":["20etyy008"],"award-info":[{"award-number":["20etyy008"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,9,14]]},"abstract":"<jats:p>Objective. To compare the clinical efficacy of different insulin administration methods and blood glucose monitoring methods in treating type 1 diabetes mellitus in children. Methods. Patients were divided into four groups: multiple daily injection (MDI)\u2009+\u2009fingertip blood glucose detection, continuous subcutaneous insulin infusion (CSII)\u2009+\u2009fingertip blood glucose detection, MDI\u2009+\u2009continuous glucose monitoring system (CGMS), and CSII\u2009+\u2009CGMS. After six months of treatment, followed by telephone and at least once a month in an outpatient clinic, insulin doses were adjusted according to the children\u2019s blood glucose levels. Blood glucose control and the daily dose of insulin were compared among the four groups after treatment, and the incidence of hypoglycemia in each group was recorded during the treatment. We also compare the incidence of the adverse event among the four groups. Results. 6 months later, the levels of HbA1c, FBG, and two h PG in each group were lower than those before treatment. There were significant differences in HbA1c, two h PG, and the daily insulin dose among the four groups. There were differences in the frequency of hypoglycemia among all the groups. The frequency of hypoglycemia in groups C and D was lower than in group A. Conclusions. CSII was better than MDI, and the blood glucose monitoring effect of CGMS was better than the fingertip blood glucose detection. The patients treated with CSII combined with CGMS had the best clinical efficacy. The patients treated with CSII combined with CGMS had the lowest adverse events incidence.<\/jats:p>","DOI":"10.1155\/2022\/2862682","type":"journal-article","created":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T15:35:05Z","timestamp":1663169705000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Comparison of the Efficacy of Different Insulin Administration and Blood Glucose Monitoring Methods in the Treatment of Type 1 Diabetes Mellitus in Children"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6459-888X","authenticated-orcid":true,"given":"Qian","family":"Deng","sequence":"first","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7161-3910","authenticated-orcid":true,"given":"Yuqing","family":"Chen","sequence":"additional","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjuan","family":"Cai","sequence":"additional","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanping","family":"Han","sequence":"additional","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juanjuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Endocrine Metabolism Department, Anhui Provincial Children\u2019s Hospital, Hefei 23000, Anhui, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44113"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69001-2"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12644"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.17458\/per.vol17.2020.tol.epidemiologychildtype1diabetes"},{"issue":"10","key":"5","first-page":"1826","article-title":"Analysis of the effect of targeted health education on blood glucose level and nursing satisfaction in children with type 1 diabetes who are re-visited and rehospitalized","volume":"5","author":"X. 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Chen","year":"2018","journal-title":"Clinical Research in Traditional Chinese Medicine"},{"key":"14","first-page":"1027","article-title":"Correlation study on the ratio of glycated albumin\/HbA_(1C), blood sugar fluctuation range and long-term blood sugar control in patients with type 1 diabetes mellitus","volume":"12","author":"B. Wang","year":"2020","journal-title":"Chinese Journal of Endocrinology and Metabolism"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12416"},{"issue":"24","key":"16","first-page":"1553","article-title":"Long-termfollow-up and efficacy analysis of insulin pump therapy for children with type 1 diabetes in Qingdao [J]","volume":"20","author":"J. Wang","year":"2020","journal-title":"Chinese Journal of Practical Pediatrics"},{"issue":"9","key":"17","first-page":"667","article-title":"Guidelines for clinical application of continuous glucose monitoring in China (2017 edition) [J]","volume":"25","author":"D. Branch of Chinese Medical Association","year":"2017","journal-title":"Chinese Journal of Diabetes"},{"issue":"9","key":"18","first-page":"1181","article-title":"Consistency study of continuous blood glucose monitoring system and scanning blood glucose monitoring system in judging dawn phenomenon in patients with type 2 diabetes","volume":"27","author":"M. Li","year":"2021","journal-title":"Chinese Journal of Modern Nursing"},{"key":"19","first-page":"367","article-title":"Application of real-time continuous blood glucose monitoring in type 1 diabetes outpatient management system","volume":"05","author":"Y. Shen","year":"2017","journal-title":"Chinese Journal of Endocrinology and Metabolism"},{"issue":"2","key":"20","first-page":"264","article-title":"Analysis of the influencing factors of hypoglycemia events in children with type 1 diabetes","volume":"37","author":"Y. 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