{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:02:42Z","timestamp":1767168162290,"version":"build-2238731810"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T00:00:00Z","timestamp":1654560000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019037","name":"Key Science and Technology Research Project in Jiangxi Province Department of Education","doi-asserted-by":"publisher","award":["GJJ201517"],"award-info":[{"award-number":["GJJ201517"]}],"id":[{"id":"10.13039\/501100019037","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,6,7]]},"abstract":"<jats:p>Objective. To investigate the protective effect and mechanism of curcumin on intestinal barrier function in rats with enterogenic sepsis. Methods. Rats were divided into Sham group (Sham), Model group (Model), low-dose curcumin group (100\u2009mg\/kg), and high-dose curcumin group (200\u2009mg\/kg), with 10 rats in each group. Sepsis model was established in model group, low-dose curcumin group, and high-dose curcumin group. After drug intervention, hematoxylin-eosin (HE) staining was used to observe the histopathological changes of small intestine in each group. The levels of TNF-\u03b1, IL-1\u03b2, and IL-6 in serum and intestinal tissues of rats were determined by ELISA. The expression of ZO-1, occludin, and claudin-1 in ileum was detected by QRT-PCR and Western blot. Western blotting was used to detect the expression of ERK\/JNK signaling pathway, NF-\u03baB p65, apoptosis-related proteins Caspase-3, and TNF-\u03b1 in rat intestinal tissues. Results. HE staining showed that curcumin treatment reduced epithelial cell shedding, interstitial edema, and apoptosis. Compared with model group, DAO activity, serum intestinal fatty acid binding protein (I-FABP), TNF-\u03b1, IL-6, and IL-1\u03b2 expression in curcumin group were decreased in a dose-dependent manner. Curcumin can upregulate the mRNA and protein expression levels of ZO-1, occludin, and claudin-1 in ileum of CLP-induced rats. In addition, curcumin inhibits NF-\u03baB p65 activation and apoptosis by regulating ERK\/JNK signaling pathway. Conclusion. Curcumin can reduce inflammatory response and upregulate the expression of intestinal tight junction proteins ZO-1, occludin, and claudin-1 in rats with enterogenic sepsis, and protect intestinal barrier function.<\/jats:p>","DOI":"10.1155\/2022\/2884522","type":"journal-article","created":{"date-parts":[[2022,6,7]],"date-time":"2022-06-07T18:20:38Z","timestamp":1654626038000},"page":"1-9","source":"Crossref","is-referenced-by-count":5,"title":["Curcumin Improved Intestinal Epithelial Barrier Integrity by Up-Regulating ZO-1\/Occludin\/Claudin-1 in Septic Rats"],"prefix":"10.1155","volume":"2022","author":[{"given":"Xiaofeng","family":"Liu","sequence":"first","affiliation":[{"name":"Intensive Care Unit, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3110-2635","authenticated-orcid":true,"given":"Hongquan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Intensive Care Unit, First Affiliated Hospital of Gannan Medical University, Ganzhou City, Jiangxi Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra043632"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1177\/2050312119835043"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(18)30696-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000000565"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1097\/shk.0000000000001098"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2019.02.055"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0126-x"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/asj.13357"},{"issue":"6","key":"9","first-page":"481","article-title":"Structure and function of tight junctions. 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