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The underlying mechanisms associated with sepsis\u2010induced myocardial injury (SIMI) include cardiac contractility, inflammatory response, oxidative stress, and apoptosis. Kudzu celery decoction (KCD) is composed of a variety of traditional Chinese medicine (TCM) such as kudzu and celery. The previous study found that the main ingredients in kudzu and celery have also been proved to have anti\u2010inflammatory, antioxidative, and other biological activities. In this study, the therapeutic effects of KCD were evaluated in the cecal ligation and puncture (CLP) model of BALB\/c mice. The effects of KCD on cardiac function, myocardium damage, inflammation, and fibrosis in CLP\u2010injured mice were analyzed with echocardiography, histological staining, and quantitative real\u2010time PCR. The results showed that KCD treatment improved the anal temperature, sepsis score, blood routine parameters, and blood biochemical parameters in CLP\u2010injured mice. Then, we observed that KCD could remarkably alleviate cardiac dysfunction, myocardial fibrosis, oxidative stress, and inflammation in CLP\u2010injured mice. In this study, we confirmed that KCD has a significant protective effect on SIMI, which may favor KCD a potential cardioprotective drug candidate to alleviate SIMI and further amplify the application of TCM prescription in clinic.<\/jats:p>","DOI":"10.1155\/2022\/2886932","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T01:35:10Z","timestamp":1651714510000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Kudzu Celery Decoction Exerts Protection against Sepsis\u2010Induced Myocardial Injury"],"prefix":"10.1155","volume":"2022","author":[{"given":"Lin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huadong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mengfan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qibing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhenxing","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1413-2111","authenticated-orcid":false,"given":"Xuezeng","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1163-2359","authenticated-orcid":false,"given":"Yang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,5,4]]},"reference":[{"key":"e_1_2_13_1_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0287"},{"key":"e_1_2_13_2_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00037.2012"},{"key":"e_1_2_13_3_2","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.106.678359"},{"key":"e_1_2_13_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.069"},{"key":"e_1_2_13_5_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201211-1983OC"},{"key":"e_1_2_13_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2927131"},{"key":"e_1_2_13_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2019.04.004"},{"key":"e_1_2_13_8_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00692"},{"key":"e_1_2_13_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/1756-0500-7-233"},{"key":"e_1_2_13_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-020-00492-2"},{"key":"e_1_2_13_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6659240"},{"key":"e_1_2_13_12_2","doi-asserted-by":"publisher","DOI":"10.1080\/07388551.2017.1312275"},{"key":"e_1_2_13_13_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.0000143081.13042.04"},{"key":"e_1_2_13_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00669.x"},{"key":"e_1_2_13_15_2","doi-asserted-by":"publisher","DOI":"10.1378\/chest.101.3.810"},{"key":"e_1_2_13_16_2","first-page":"901","article-title":"Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction","volume":"12","author":"Zeng X. 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