{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T21:22:05Z","timestamp":1789593725260,"version":"build-2803163510"},"reference-count":64,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Oncology"],"published-print":{"date-parts":[[2022,11,29]]},"abstract":"<jats:p>Objective. The objective is to explore the effectiveness and safety of CAR T-cell therapy in advanced relapsed\/refractory central nervous system B-cell lymphoma and compare the impact of autologous stem cell transplantation (ASCT) plus CAR T-cell therapy versus sequential CART therapy on the survival of patients. Methods. The retrospective analysis was based on the data of 17 patients with advanced relapsed\/refractory central nervous system B-cell lymphoma. Bridging chemotherapy was applied before CAR T-cell infusion to further reduce the tumor burden. For patients with autologous hematopoietic stem cell successful collection, CD19\/20\/22CAR T-cell immunotherapy following ASCT was performed with the thiotepa-containing conditioning regimen, while sequential CD19\/CD20\/CD22CAR T-cell therapy was applied. For lymphodepletion, patients received bendamustine or fludarabine monotherapy or fludarabine combined with cyclophosphamide pre-CART-cell infusion. Results. Out of the 17 patients, 8 completed ASCT plus CART cell therapy, while 9 patients completed CART cell alone therapy. In efficacy assessment at 3 months after infusion, the objective response rate (ORR) was 12\/17 (71%) and the complete response rate (CRR) was 11\/17 (65%). The CRR of the ASCT group and non-ASCT was 100% and 44.4%, respectively (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). The median progression-free survival was 16.3 (2.6\u201324.5) months, and the median overall survival was 19.3 (6\u201324.5) months. Patients who underwent ASCT plus CART cell therapy had significantly longer PFS (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.01<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>) and OS (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.01<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). Grade 3 or higher immune effector cell-associated neurologic toxicity syndrome (\u2265grade 3 ICANS) and cytokine release syndrome (\u2265grade 3 CRS) events occurred in 29% and 41% of the patients, respectively. No treatment-related death occurred. Conclusion. The CAR T-cell therapy could augment its efficacy in the treatment of advanced relapsed\/refractory CNS B-cell lymphoma, while ASCT in combination with CART can induce durable responses and OS with a manageable side effect.<\/jats:p>","DOI":"10.1155\/2022\/2900310","type":"journal-article","created":{"date-parts":[[2022,11,30]],"date-time":"2022-11-30T05:54:04Z","timestamp":1669787644000},"page":"1-20","source":"Crossref","is-referenced-by-count":26,"title":["The Autologous Hematopoietic Stem Cells Transplantation Combination-Based Chimeric Antigen Receptor T-Cell Therapy Improves Outcomes of Relapsed\/Refractory Central Nervous System B-Cell Lymphoma"],"prefix":"10.1155","volume":"2022","author":[{"given":"Fei","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Adult Lymphoma, Beijing Boren Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peihao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of 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