{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:16:22Z","timestamp":1789186582994,"version":"build-2803163510"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T00:00:00Z","timestamp":1649462400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2019JJ50878"],"award-info":[{"award-number":["2019JJ50878"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["81801394"],"award-info":[{"award-number":["81801394"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2019JJ50878"],"award-info":[{"award-number":["2019JJ50878"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801394"],"award-info":[{"award-number":["81801394"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiovascular Therapeutics"],"published-print":{"date-parts":[[2022,4,9]]},"abstract":"<jats:p>Background. Association between abdominal obesity and development of heart failure (HF) with preserved ejection fraction (HFpEF) between the sexes is not completely understood. Objectives. This study evaluated the association between abdominal obesity and the risk of all-cause mortality in patients with HFpEF while performing a gender outcome comparison. Methods. A post hoc analysis was undertaken from the American cohort of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT). The primary outcome (all-cause mortality) and the secondary outcomes (cardiovascular mortality, hospitalization for HF, stroke, and MI) were evaluated via Cox proportional hazards models to compare the hazard ratios (HRs) between sexes in HFpEF patients. Abdominal obesity was defined as a waist circumference of \u2265102\u2009cm in men and \u226588\u2009cm in women. Results. A total of 3320 HFpEF patients (1620 men [48.80%] and 1700 women [51.20%]) were included in the analysis. The mean follow-up period was <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mn>3.4<\/a:mn>\n                        <a:mo>\u00b1<\/a:mo>\n                        <a:mn>1.7<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula> years, with 503 patients dying during that time. After multivariable adjustment, abdominal obesity was significantly associated with an increased risk of all-cause mortality in males (adjusted HR: 1.32; 95% confidence interval [CI]: 1.02 to 1.71; <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.038<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Abdominal obesity was associated with hospitalization for HF in both male (adjusted HR: 1.39; 95% CI: 1.01 to 1.93; <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.045<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and female patients (adjusted HR: 1.15; 95% CI: 1.18 to 3.28; <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>0.010<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). Conclusions. Abdominal obesity is associated with increased risks of all-cause mortality in the male but not the female HFpEF population and is associated with increased risks of hospitalization for HF in both sexes.<\/jats:p>","DOI":"10.1155\/2022\/2950055","type":"journal-article","created":{"date-parts":[[2022,4,9]],"date-time":"2022-04-09T19:20:08Z","timestamp":1649532008000},"page":"1-11","source":"Crossref","is-referenced-by-count":4,"title":["Abdominal Obesity Is Associated with an Increased Risk of All-Cause Mortality in Males but Not in Females with HFpEF"],"prefix":"10.1155","volume":"2022","author":[{"given":"Liyao","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China"},{"name":"Department of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China"},{"name":"Department of Blood Transfusion, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaowei","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5802-2910","authenticated-orcid":true,"given":"Shi","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The Second Xiangya Hospital of Central South University, Changsha, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","first-page":"1167","article-title":"ESC guidelines for the diagnosis and treatment of acute and chronic","volume":"69","author":"P. Ponikowski","year":"2016","journal-title":"Revista Espa\u00f1ola de Cardiolog\u00eda"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.65"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0323-2"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz641"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.09.1111"},{"issue":"10","key":"6","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.1002\/ejhf.2254","article-title":"Obesity, venous capacitance, and venous compliance in heart failure with preserved ejection fraction","volume":"23","author":"H. 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