{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:03:42Z","timestamp":1767168222153,"version":"build-2238731810"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"vor","delay-in-days":89,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Oxidative stress plays a key role in the initiation and progression of metabolic diseases, including obesity. Preventing the accumulation of reactive oxygen species and oxidative damage to macromolecules is a beneficial strategy for reducing comorbidities associated with obesity. Fruits from the\n                    <jats:italic>Spondias<\/jats:italic>\n                    genus are known for their antioxidant activity, but they are not available year\u2010round due to their seasonality. In this context, we investigated the antioxidant activity and identified the chemical constituents of the aqueous extract of the stem bark of\n                    <jats:italic>Spondias purpurea<\/jats:italic>\n                    L. (EBSp). Additionally, we evaluated the effect of EBSp consumption on metabolic parameters in mice with obesity induced by a high\u2010fat diet. Chemical analyses revealed 19 annotated compounds from EBSp, including flavan\u20103\u2010ols, proanthocyanidins, methoxylated coumarin, and gallic and ellagic acids, besides other phenolic compounds. In vitro, EBSp showed antioxidant activity through the scavenging of the free radicals and the protection of macromolecules against oxidative damage. Cellular assays revealed that EBSp reduced the levels of malondialdehyde produced by erythrocytes exposed to the oxidizing agent AAPH. Flow cytometry studies showed that EBSp reduced reactive oxygen species levels in human peripheral blood mononuclear cells treated with hydrogen peroxide. Obese mice treated with EBSp (400\u2009mg.kg\n                    <jats:sup>-1<\/jats:sup>\n                    ) for 60 days showed reduced levels of malondialdehyde in the heart, liver, kidneys, and nervous system. The total cholesterol levels in mice treated with EBSp reached levels similar to those after treatment with the drug simvastatin. Together, the results show that the combination of the different phenolic compounds in\n                    <jats:italic>S. purpurea<\/jats:italic>\n                    L. bark promotes antioxidant effects in vitro and in vivo, resulting in cytoprotection in the context of oxidative stress associated with obesity and a reduction in hypercholesterolemia. From a clinical perspective, the reduction in oxidative stress in obese individuals contributes to the reduction in the emergence of comorbidities associated with this metabolic syndrome.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3046483","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T15:50:07Z","timestamp":1648741807000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["[Retracted] Spondias purpurea L. Bark Extract Protects against Oxidative Stress and Reduces Hypercholesterolemia in Mice Fed High\u2010Fat Diet"],"prefix":"10.1155","volume":"2022","author":[{"given":"K\u00e1tia A.","family":"Antunes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamaeh","family":"Monteiro-Alfredo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janielle S. M.","family":"Cunha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscila P. T.","family":"Espindola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio F.","family":"Ramalho de Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Tarc\u00edsio G.","family":"de Carvalho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nelson L. C.","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise B.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia C. F.","family":"Olinto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson L.","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5764-2125","authenticated-orcid":false,"given":"Kely","family":"de Picoli Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,31]]},"reference":[{"key":"e_1_2_9_1_2","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00047.2003"},{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.21276\/apjhs.2014.1.4.15"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1582-4934.2009.00897.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.140"},{"key":"e_1_2_9_5_2","first-page":"219","article-title":"Studies on free radicals, antioxidants, and co-factors","volume":"2","author":"Rahman K.","year":"2007","journal-title":"Clinical Interventions in Aging"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2006.07.001"},{"key":"e_1_2_9_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2015.04.040"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2009.03.091"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-016-0077-6"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/6593073"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5613704"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1021\/acsfoodscitech.1c00107"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0042-117774"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.12.106"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2011.04.003"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-803951-9.00016-1"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23040965"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2017.10.131"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6882-8-63"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S2221-1691(13)60139-2"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2015.12.009"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.6b00703"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2014.6062"},{"key":"e_1_2_9_24_2","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/5080843"},{"key":"e_1_2_9_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.08.068"},{"key":"e_1_2_9_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodres.2015.04.021"},{"key":"e_1_2_9_27_2","doi-asserted-by":"publisher","DOI":"10.1002\/jat.1559"},{"key":"e_1_2_9_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108625"},{"key":"e_1_2_9_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.08.038"},{"key":"e_1_2_9_30_2","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2018.0193"},{"key":"e_1_2_9_31_2","doi-asserted-by":"publisher","DOI":"10.3390\/nu12082393"},{"key":"e_1_2_9_32_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-45600-6"},{"key":"e_1_2_9_33_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2018.00017"},{"key":"e_1_2_9_34_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI21625"},{"key":"e_1_2_9_35_2","article-title":"Is obesity associated with increased plasma lipid peroxidation and oxidative stress in women?","volume":"2","author":"Amirkhizi F.","year":"2010","journal-title":"ARYA Atherosclerosis"},{"key":"e_1_2_9_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0801536"},{"key":"e_1_2_9_37_2","doi-asserted-by":"publisher","DOI":"10.1590\/0001-3765201620160041"},{"key":"e_1_2_9_38_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.08.037"},{"key":"e_1_2_9_39_2","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030484"},{"key":"e_1_2_9_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-010-0139-2"},{"key":"e_1_2_9_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2007.11.023"},{"key":"e_1_2_9_42_2","first-page":"751","article-title":"Quercetin permeability across blood-brain barrier and its effect on the viability of U251 cells","volume":"41","author":"Ren S.","year":"2010","journal-title":"Sichuan Da Xue Xue Bao. 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