{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:53:45Z","timestamp":1775609625097,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T00:00:00Z","timestamp":1651795200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Yunnan Provincial Department of Education Project","award":["2018JS154"],"award-info":[{"award-number":["2018JS154"]}]},{"name":"Yunnan Provincial Department of Education Project","award":["2019-03-10-008"],"award-info":[{"award-number":["2019-03-10-008"]}]},{"name":"Yunnan Provincial Department of Education Project","award":["2019FE001-016"],"award-info":[{"award-number":["2019FE001-016"]}]},{"name":"Yunnan Provincial Department of Education Project","award":["2017FE467-205"],"award-info":[{"award-number":["2017FE467-205"]}]},{"name":"Yunnan Provincial Department of Education Project","award":["2020AC20022"],"award-info":[{"award-number":["2020AC20022"]}]},{"name":"Kunming Municipal Health Commission","award":["2018JS154"],"award-info":[{"award-number":["2018JS154"]}]},{"name":"Kunming Municipal Health Commission","award":["2019-03-10-008"],"award-info":[{"award-number":["2019-03-10-008"]}]},{"name":"Kunming Municipal Health Commission","award":["2019FE001-016"],"award-info":[{"award-number":["2019FE001-016"]}]},{"name":"Kunming Municipal Health Commission","award":["2017FE467-205"],"award-info":[{"award-number":["2017FE467-205"]}]},{"name":"Kunming Municipal Health Commission","award":["2020AC20022"],"award-info":[{"award-number":["2020AC20022"]}]},{"name":"Scientific and Technological Development Project of Yunnan Province","award":["2018JS154"],"award-info":[{"award-number":["2018JS154"]}]},{"name":"Scientific and Technological Development Project of Yunnan Province","award":["2019-03-10-008"],"award-info":[{"award-number":["2019-03-10-008"]}]},{"name":"Scientific and Technological Development Project of Yunnan Province","award":["2019FE001-016"],"award-info":[{"award-number":["2019FE001-016"]}]},{"name":"Scientific and Technological Development Project of Yunnan Province","award":["2017FE467-205"],"award-info":[{"award-number":["2017FE467-205"]}]},{"name":"Scientific and Technological Development Project of Yunnan Province","award":["2020AC20022"],"award-info":[{"award-number":["2020AC20022"]}]},{"name":"Science and Technology Base and Talent Project of Guangxi Autonomous Region","award":["2018JS154"],"award-info":[{"award-number":["2018JS154"]}]},{"name":"Science and Technology Base and Talent Project of Guangxi Autonomous Region","award":["2019-03-10-008"],"award-info":[{"award-number":["2019-03-10-008"]}]},{"name":"Science and Technology Base and Talent Project of Guangxi Autonomous Region","award":["2019FE001-016"],"award-info":[{"award-number":["2019FE001-016"]}]},{"name":"Science and Technology Base and Talent Project of Guangxi Autonomous Region","award":["2017FE467-205"],"award-info":[{"award-number":["2017FE467-205"]}]},{"name":"Science and Technology Base and Talent Project of Guangxi Autonomous Region","award":["2020AC20022"],"award-info":[{"award-number":["2020AC20022"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,5,6]]},"abstract":"<jats:p>Diabetes cardiomyopathy has metabolic disorder and abnormality of cardiomyocytes, which is closely related to autophagy or apoptosis of cardiomyocytes. Scutellarin (SCU) is an important monomer extracted from Erigeron breviscapus (vant.) Hand.-Mazz. This study was conducted to investigate the function of SCU on apoptosis and autophagy of myocardial cells. We established a model of type 2 diabetic cardiomyopathy by high-fat and high-sugar diet. The results indicated that SCU downregulated blood glucose, total cholesterol (TC), triglyceride (TG), and low-density lipoprotein (LDL) levels and upregulated high-density lipoprotein (HDL) level. In addition, SCU downregulated lactic dehydrogenase 1 (LDH1) and creatine kinase (CK) levels. Meanwhile, SCU improved the myocardium morphology and reduced myocardial apoptosis. Furthermore, SCU promoted the mRNA and protein expression of autophagy-related factors (Beclin-1 and LC3-II) and inhibited the mRNA and protein expression of apoptosis-related factors (caspase-3, caspase-8, caspase-9, caspase-12, Bax, and Cyt-C). In conclusion, SCU can promote autophagy signal pathway by upregulating the autophagy-related factors and inhibit the apoptotic signal pathway by downregulating apoptosis-related factors, thereby relieving type 2 diabetic cardiomyopathy (T2DC).<\/jats:p>","DOI":"10.1155\/2022\/3058354","type":"journal-article","created":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T19:23:00Z","timestamp":1651864980000},"page":"1-10","source":"Crossref","is-referenced-by-count":20,"title":["Scutellarin Improves Type 2 Diabetic Cardiomyopathy by Regulating Cardiomyocyte Autophagy and Apoptosis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yanmei","family":"Su","sequence":"first","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China"},{"name":"Kunming Angel Women\u2019s and Children\u2019s Hospital, Kunming, Yunnan 650031, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoming","family":"Fan","sequence":"additional","affiliation":[{"name":"Gaungxi Key Laboratory of Diabetic Systems Medicine, Guilin Medical University, Guangxi Zhuang Autonomous Region 541004, China"},{"name":"Department of Human Anatomy, School of Basic Medicine, Guilin Medical University, Guangxi Zhuang Autonomous Region 541004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siman","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2824-689X","authenticated-orcid":true,"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1521-0425","authenticated-orcid":true,"given":"Ming","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Cell Biology and Medical Genetics, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3101-5403","authenticated-orcid":true,"given":"Shude","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, School of Basic Medicine, Kunming Medical University, Kunming, Yunnan 650500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2017.151"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1080\/03007995.2018.1445620"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.09.092"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2016.10.021"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25785"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.117.008024"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11101465"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-011-1127-x"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108647"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182467"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2013.03.027"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.538407"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.04.027"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.0c00529"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.11100"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22020817"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113363"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0420-305R"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1007\/s13238-014-0089-1"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M204973200"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.650193"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.4161\/auto.36076"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28820"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.9719"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2013.11.028"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-013-1208-8"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.25303"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.08.098"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3058354.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3058354.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3058354.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,6]],"date-time":"2022-05-06T19:23:13Z","timestamp":1651864993000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/3058354\/"}},"subtitle":[],"editor":[{"given":"Chengwu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,6]]},"references-count":28,"alternative-id":["3058354","3058354"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3058354","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,6]]}}}