{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:11:13Z","timestamp":1767168673467,"version":"build-2238731810"},"reference-count":51,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006261","name":"Taif University","doi-asserted-by":"publisher","award":["1-441-95"],"award-info":[{"award-number":["1-441-95"]}],"id":[{"id":"10.13039\/501100006261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,1,30]]},"abstract":"<jats:p>\n                    Background. Diabetes mellitus type 2 and vitamin D deficiency are both prevalent in the Saudi Arabia. Vitamin D deficiency treatment with supplements carries a risk of intoxication. Aim. The present study is aimed at elucidating the effect of exercise on modulation of metabolic status and vitamin D level in patients with type 2 diabetes mellitus (T2DM). Methods. A sum of 110 type 2 diabetic patients were voluntarily enrolled for the present investigation by dividing them into two separate groups (55 individuals for each group), the diabetic study group and diabetic control group. The diabetic study group was engaged in the training program using treadmill exercise. Laboratory parameters were monitored before and after the training program. Results. There were significant elevation in the diabetic study group compared to diabetic control group regarding postexercise vitamin D level, high-density lipoprotein (HDL) (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    value \u2264 0.001, 0.045; respectively). In addition, triglycerides, low-density lipoprotein (LDL), glycosylated hemoglobin (HbA1C), and homeostatic model assessment-insulin resistance (HOMA-IR) were significantly decreased (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    value &lt; 0.001 for all mentioned parameters). Moreover, there were significant higher level in postexercise parameters as compared to preexercise level in the diabetic study group. Conclusion. The exercise training program improved the metabolic control and vitamin D level after three months of intervention.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3059629","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T21:07:26Z","timestamp":1643576846000},"page":"1-7","source":"Crossref","is-referenced-by-count":1,"title":["Effect of Application of Treadmill Training on Metabolic Control and Vitamin D Level in Saudi Patients with Type 2 Diabetes Mellitus"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6022-0772","authenticated-orcid":true,"given":"Ahmad","family":"El Askary","sequence":"first","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Shafie","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7580-8667","authenticated-orcid":true,"given":"Mazen","family":"Almehmadi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0802-8062","authenticated-orcid":true,"given":"Hatem H.","family":"Allam","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lamiaa K.","family":"Elsayyad","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asmaa F.","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Medical Physiology, College of Medicine, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bader B.","family":"Althobaiti","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratories, King Abdulaziz Specialist Hospital in Taif, Ministry of Health, Taif, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed Mansour","family":"Khalifa","sequence":"additional","affiliation":[{"name":"Department of Human Physiology, Faculty of Medicine, Cairo University, Egypt"},{"name":"Department of Human Physiology, College of Medicine, King Saud University, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamer","family":"Saber","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aisha H.","family":"Alharthi","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8008-3368","authenticated-orcid":true,"given":"Amal F.","family":"Gharib","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"4","key":"1","first-page":"24","article-title":"Hypovitaminosis D: a widespread epidemic","volume":"63","author":"E. P. Cherniack","year":"2008","journal-title":"Geriatrics"},{"issue":"1","key":"2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4103\/jfcm.JFCM_73_17","article-title":"Vitamin D deficiency in Saudi Arabians: a reality or simply hype: a meta-analysis (2008\u20132015)","volume":"25","author":"H. 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