{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T22:33:09Z","timestamp":1774823589535,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:00:00Z","timestamp":1656201600000},"content-version":"vor","delay-in-days":176,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Previous studies have suggested that guarana (<jats:italic>Paullinia cupana<\/jats:italic>) and a\u00e7ai (<jats:italic>Euterpe oleracea<\/jats:italic>) have antioxidant, anti\u2010inflammatory, and proliferative properties, indicating their potential therapeutic action in wound healing. We produced a conjugated guarana\u2010a\u00e7ai (GA) extract and tested its healing action on earthworms (<jats:italic>Eisenia fetida<\/jats:italic>) subjected to tail amputation by surgical incision. <jats:italic>Methods<\/jats:italic>. Extract from roasted guarana seeds and fresh a\u00e7ai seed berries was produced. The antioxidant and genoprotective capacity of GA extract was tested. The concentration with the most remarkable healing potential was used in subsequent tests. The last three posterior segments of the clitellate earthworm tail reared under standardized conditions were surgically amputated. Next, topical PBS or GA extract was applied to the surgical wound. The rate of cell migration and tissue regeneration at the local wound site was histologically evaluated after the procedure. Expression of the SOX4 gene that acts in epithelial\u2010to\u2010mesenchymal transition was determined by RT\u2010qPCR. <jats:italic>Results<\/jats:italic>. Sixteen bioactive molecules, including some previously described substances, were identified. All tested concentrations exhibited antioxidant and genoprotective effects. The GA extract accelerated the healing processes as observed through macroscopic and histological analyses and increased expression of SOX4. <jats:italic>Conclusion<\/jats:italic>. The GA extract has a potential role in the healing of surgically induced wounds.<\/jats:p>","DOI":"10.1155\/2022\/3094362","type":"journal-article","created":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T15:20:09Z","timestamp":1656256809000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Amazonian Guarana\u2010 and A\u00e7ai\u2010Conjugated Extracts Improve Scratched Fibroblast Healing and <i>Eisenia fetida<\/i> Surgical Tail Amputation by Modulating Oxidative Metabolism"],"prefix":"10.1155","volume":"2022","author":[{"given":"Fellipe D.","family":"Felin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ednea A.","family":"Maia-Ribeiro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carollina D.","family":"Felin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nath\u00e1lia A. 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C. A. FelinF. D. Maia-RibeiroE. A. BarbisanF. FelinC. D. TeixeiraC. F. RoggiaI. TurraB. O. andda CruzI. B. M. Amazonian guaran\u00e1 and a\u00e7a\u00ed: conjugated extract improves the healing of Eisenia fetida submitted to tail-amputation. 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