{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:24:48Z","timestamp":1740173088600,"version":"3.37.3"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T00:00:00Z","timestamp":1660348800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007046","name":"Wuhan University","doi-asserted-by":"publisher","award":["MS2019033","2018WNLOKF023","82171986"],"award-info":[{"award-number":["MS2019033","2018WNLOKF023","82171986"]}],"id":[{"id":"10.13039\/501100007046","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008416","name":"Wuhan National Laboratory for Optoelectronics","doi-asserted-by":"publisher","award":["MS2019033","2018WNLOKF023","82171986"],"award-info":[{"award-number":["MS2019033","2018WNLOKF023","82171986"]}],"id":[{"id":"10.13039\/501100008416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["MS2019033","2018WNLOKF023","82171986"],"award-info":[{"award-number":["MS2019033","2018WNLOKF023","82171986"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Immunology Research"],"published-print":{"date-parts":[[2022,8,13]]},"abstract":"<jats:p>Multiple myeloma (MM) is a hematological malignancy of plasma cell origin. Cardiac amyloidosis (CA) is a common form of heart damage caused by MM and is associated with a poor prognosis. This study was a prospective cohort study and was aimed at evaluating the clinical predictive value of extracellular volume fraction (ECV) based on cardiovascular magnetic resonance (CMR) T1 mapping for cardiac amyloidosis and cardiac dysfunction in MM patients. Fifty-one newly diagnosed MM patients in Zhongnan Hospital of Wuhan University were enrolled in the study. A total of 19 patients (19\/51; 37.25%) developed CA. The basal ECV of CA group was significantly higher than that of the non-CA group (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.01<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). Multivariate logistic regression analysis showed that basal ECV (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mtext>OR<\/c:mtext>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>1.551<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>, 95% CI 1.084-2.219, <jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and LDH1 level (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mtext>OR<\/g:mtext>\n                        <g:mo>=<\/g:mo>\n                        <g:mn>1.150<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>, 95% CI 1.010-1.310, <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>) were two independent risk factors for CA. Further study demonstrated that basal ECV in the heart failure group was significantly higher than that of the nonheart failure group (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.01<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Notably, ROC curve showed that basal ECV had a good predictive value for CA and heart failure, with AUC of 0.911 and 0.893 (all <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mi>p<\/m:mi>\n                        <m:mo>&lt;<\/m:mo>\n                        <m:mn>0.01<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>), and the best cutoff values of 38.35 and 37.45, respectively. Taken together, basal ECV is a good predictor of CA and heart failure for MM patients.<\/jats:p>","DOI":"10.1155\/2022\/3094933","type":"journal-article","created":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T19:05:11Z","timestamp":1660417511000},"page":"1-12","source":"Crossref","is-referenced-by-count":1,"title":["Extracellular Volume Fraction Based on Cardiac Magnetic Resonance T1 Mapping: An Effective Way to Evaluate Cardiac Injury Caused by Cardiac Amyloidosis in Patients with Multiple Myeloma"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0475-9634","authenticated-orcid":true,"given":"Minghui","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9066-8503","authenticated-orcid":true,"given":"Liang","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9779-8703","authenticated-orcid":true,"given":"Zhaoxia","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7933-238X","authenticated-orcid":true,"given":"Qian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-1465","authenticated-orcid":true,"given":"Balu","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4557-9362","authenticated-orcid":true,"given":"Xiaoyan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0293-7510","authenticated-orcid":true,"given":"Yalan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5001-0782","authenticated-orcid":true,"given":"Tingting","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8068-3918","authenticated-orcid":true,"given":"Meixing","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9846-7578","authenticated-orcid":true,"given":"Yong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5860-7812","authenticated-orcid":true,"given":"Guohong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Radiology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0982-0382","authenticated-orcid":true,"given":"Fuling","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology, Zhongnan Hospital of Wuhan University, Wuhan 430071, 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