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It offers striking selectivity to cancer cells compared to noncancerous human fibroblasts. The data reveal that the complex induces ferroptosis in rhabdomyosarcoma cells, likely due to interfering with iron metabolism. Importantly, it can kill both bulk and stem rhabdomyosarcoma cells. To the best of our knowledge, this is the first compound based on metal other than Fe capable of inducing ferroptosis in cancer cells.<\/jats:p>","DOI":"10.1155\/2022\/3095749","type":"journal-article","created":{"date-parts":[[2022,4,23]],"date-time":"2022-04-23T20:35:13Z","timestamp":1650746113000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Gallium(III) Complex with Cloxyquin Ligands Induces Ferroptosis in Cancer Cells and Is a Potent Agent against Both Differentiated and Tumorigenic Cancer Stem Rhabdomyosarcoma Cells"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-7115","authenticated-orcid":false,"given":"Monika","family":"Hreusova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4381-8403","authenticated-orcid":false,"given":"Vojtech","family":"Novohradsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1640-6163","authenticated-orcid":false,"given":"Lenka","family":"Markova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2706-6491","authenticated-orcid":false,"given":"Hana","family":"Kostrhunova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6923-8816","authenticated-orcid":false,"given":"Ivan","family":"Poto\u010d\u0148\u00e1k","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8233-1393","authenticated-orcid":false,"given":"Viktor","family":"Brabec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5279-5381","authenticated-orcid":false,"given":"Jana","family":"Kasparkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,23]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/s1040-8428(01)00225-6"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/s0162-0134(02)00419-1"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm0612618"},{"key":"e_1_2_8_4_2","first-page":"353","article-title":"Clinical pharmacology of gallium chloride after oral administration in lung cancer patients","volume":"9","author":"Collery P.","year":"1989","journal-title":"Anticancer Research"},{"key":"e_1_2_8_5_2","first-page":"521","article-title":"Preclinical and early clinical development of the antitumor gallium complex KP46 (FFC11)","volume":"9","author":"Collery P.","year":"2006","journal-title":"Metal Ions in Biology and Medicine"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1155\/mbd.2000.33"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.11.006"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1002\/anie.202008432"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.69"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1039\/c9cc08962d"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.03.026"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1039\/b902861g"},{"key":"e_1_2_8_13_2","first-page":"110","volume-title":"Metal Ions in Biology and Medicine","author":"Jakupec M. 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