{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T20:06:18Z","timestamp":1788206778476,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T00:00:00Z","timestamp":1658448000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang Medical and Health Science and Technology Project","award":["2017KY733"],"award-info":[{"award-number":["2017KY733"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,22]]},"abstract":"<jats:p>Background. The etiology of sudden deafness is still unclear. In recent years, people\u2019s life rhythm is getting faster and faster. Fatigue, environment, diet, psychology, and other factors have increased the morbidity rate of sudden deafness and improved the quality of life of patients. And work efficiency is greatly affected. Aims. A study to investigate the clinical efficacy of postauricular injection of methylprednisolone sodium succinate in the treatment of sudden deafness with type 2 diabetes. Materials and Methods. Sixty patients with sudden deafness who were treated in our hospital from January 2018 to October 2020 were selected as the subjects of this prospective study and divided into 30 cases each in the comparison group and the observation group according to the random number remainder grouping method. The comparison group was treated conventionally, and the observation group was treated with postauricular injection of methylprednisolone sodium succinate on the basis of the comparison group. Patients in the two groups were observed and compared on the 3rd, 6th, and 9th days after treatment with pure-tone hearing threshold checks and regular monitoring of blood glucose, blood rheology, and other indexes. Results. On the 7th, 14th, and 30th days after treatment, the pure-tone audiometric thresholds of the two groups were gradually decreased, and the changes in the pure-tone audiometric thresholds in the observation group were greater than those in the control group. After lunch on the 6th day and after lunch on the 9th day, it was lower than that in the control group, and the difference was statistically significant (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). 30 days after treatment, the blood viscosity, fibrin, and platelet aggregation rate of the observation group were significantly lower than those of the control group. After treatment, the clinical efficacy rate of the observation group was 96%, which was significantly higher than that of the control group, 80%, and the above differences were statistically significant (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). Conclusion. Treatment with postauricular injection of methylprednisolone sodium succinate has shown better therapeutic recovery in patients with sudden deafness, improved pure-tone hearing threshold, reduced risk of blood glucose elevation, and improved clinical outcomes for patients with sudden deafness, providing some reference for the treatment of patients with sudden deafness.<\/jats:p>","DOI":"10.1155\/2022\/3097436","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T02:35:08Z","timestamp":1658543708000},"page":"1-8","source":"Crossref","is-referenced-by-count":4,"title":["Clinical Efficacy of Retroauricular Injection of Methylprednisolone Sodium Succinate in the Treatment of Sudden Deafness with Type 2 Diabetes"],"prefix":"10.1155","volume":"2022","author":[{"given":"Zhenbo","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Lishui People\u2019s Hospital, Lishui, 323000 Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Lishui People\u2019s Hospital, Lishui, 323000 Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kairui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Lishui People\u2019s Hospital, Lishui, 323000 Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2966-8456","authenticated-orcid":true,"given":"Jing","family":"Tao","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Lishui People\u2019s Hospital, Lishui, 323000 Zhejiang Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-785"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2018.04.010"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2020.102621"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1136\/ejhpharm-2018-001693"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8120398"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1177\/1084713811408349"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000003205"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2004.10.016"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1097\/MAO.0000000000000431"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0222041"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.13703\/j.0255-2930.2019.09.029"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/14992027.2019.1689432"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/j.otorri.2018.04.010"},{"issue":"11","key":"14","first-page":"814","article-title":"Postauricular injection of compound betamethasone in the treatment of intractable low-frequency sensorineural hearing loss","volume":"42","author":"X. Yang","year":"2007","journal-title":"Chinese Journal of Otolaryngology Head and Neck Surgery"},{"issue":"2","key":"15","first-page":"144","article-title":"7.0T magnetic resonance imaging to observe the feasibility of post-auricular administration to promote drug entry into the inner ear","volume":"10","author":"K. Li","year":"2012","journal-title":"Chinese Journal of Otology"},{"issue":"4","key":"16","first-page":"359","article-title":"Efficacy analysis of post-auricular medication in the treatment of mid-high frequency descending sudden hearing loss","volume":"29","author":"F. Wang","year":"2015","journal-title":"Journal of Clinical Otolaryngology Head and Neck Surgery"},{"issue":"8","key":"17","first-page":"14110","article-title":"Efficacy of methylprednisolone sodium succinate for injection (postotic injection) on the auditory threshold and speech recognition rate of sudden deafness patients","volume":"8","author":"X. Li","year":"2015","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1186\/s13223-021-00570-1"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.3171\/2017.7.PEDS1756"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3109\/10837450.2016.1143002"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2014.03.002"},{"issue":"2","key":"22","first-page":"261","article-title":"Doxofylline and methylprednisolone sodium succinate are stable and compatible under normal injection conditions","volume":"26","author":"F. Xu","year":"2013","journal-title":"Pakistan Journal of Pharmaceutical Sciences"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1002\/phar.1189"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.2146\/ajhp110208"},{"issue":"3","key":"25","first-page":"191","article-title":"Methylprednisolone sodium succinate reduces spinal cord swelling but does not affect recovery of dogs with surgically treated thoracolumbar intervertebral disk herniation","volume":"64","author":"H. Nishida","year":"2016","journal-title":"The Japanese Journal of Veterinary Research"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.10.007"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.12669\/pjms.35.1.211"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.5455\/JPMA.9386"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-021-02610-6"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.3881\/j.issn.1000-503X.13399"}],"updated-by":[{"DOI":"10.1155\/2023\/9759346","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000},"record-id":"55517"},{"DOI":"10.1155\/2023\/9759346","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:00:00Z","timestamp":1695772800000}}],"container-title":["Computational and Mathematical Methods in Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/3097436.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/3097436.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/cmmm\/2022\/3097436.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T02:35:21Z","timestamp":1658543721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/cmmm\/2022\/3097436\/"}},"subtitle":[],"editor":[{"given":"Min","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,7,22]]},"references-count":30,"alternative-id":["3097436","3097436"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3097436","relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9759346","asserted-by":"object"}]},"ISSN":["1748-6718","1748-670X"],"issn-type":[{"value":"1748-6718","type":"electronic"},{"value":"1748-670X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7,22]]}}}