{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:16:57Z","timestamp":1767169017713,"version":"build-2238731810"},"reference-count":26,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011324","name":"Qingdao University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011324","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational Intelligence and Neuroscience"],"published-print":{"date-parts":[[2022,11,18]]},"abstract":"<jats:p>Objective. To study the effects of camrelizumab accompanied by first-line chemotherapy on serum SCC, VEGF levels, and adverse reactions in people undergoing advanced lung squamous cell carcinoma. Methods. Data sources of the study subjects were 60 people suffering from advanced squamous cell carcinoma of the lung hospitalized from January 2018 to October 2019. They were assigned to two groups, including the control group and the observation group in a random manner, and each consisted of 30 patients. Those in the observation group received camrelizumab (SHR-1210), and gemcitabine plus cisplatin (GP) chemotherapy were treated in the control group. Finally, according to the results, we compare the data of patients in both groups so as to find out the similarities and differences. Results. Among them, the effective efficiency of clinical treatment in the control group reached 36.67%, and that in the observation group reached 56.67%. Intuitively, it can be concluded that the control group showed lower results than the observed group. The observed group turned out to have higher periodic survival and progression free survival (PFS) of patients than the other group. During and after the cycle treatment, the data of SCC and VEGF were reduced to some extent, but the control group appeared to have a more evident reduction rate than the other group. Conclusion. SHR-1210 combined with chemotherapy has a considerable effect in practical application and has excellent clinical performance.<\/jats:p>","DOI":"10.1155\/2022\/3137370","type":"journal-article","created":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T18:05:25Z","timestamp":1668794725000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Camrelizumab Combined with First-Line Chemotherapy on Serum SCC, VEGF Levels, and Adverse Reactions in Patients with Advanced Squamous Cell Carcinoma of the Lung"],"prefix":"10.1155","volume":"2022","author":[{"given":"Zizong","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunpeng","family":"Xuan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanmei","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Qingdao University, Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusio, The Affiliated Qingdao Hiser Hospital of Qingdao University (Qingdao Hospital of Traditional Chinese Medicine), Qingdao 266000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Cui","sequence":"additional","affiliation":[{"name":"Operation Room, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2534-9500","authenticated-orcid":true,"given":"Xiangfeng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, The Affiliated Hospital of Qingdao University, Qingdao 266003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3268"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.21037\/tcr-21-401"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.52152\/spr\/2021.121"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.21037\/apm-21-3674"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12581"},{"issue":"2","key":"6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.52152\/spr\/2021.111","article-title":"Role of miRNAs in urological cancers","volume":"1","author":"S. 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