{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:09:58Z","timestamp":1771466998566,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,12,27]],"date-time":"2022-12-27T00:00:00Z","timestamp":1672099200000},"content-version":"vor","delay-in-days":360,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Acinetobacter baumannii<\/jats:italic> (<jats:italic>A. baumannii<\/jats:italic>) attributes 26% of the mortality rate in hospitalized patients, and the percentage can rise to 46 in patients admitted to ICU as it is a major cause of ventilator\u2010associated pneumonia. It has been nominated as the critical priority organism by WHO for which new therapeutic drugs are urgently required. To understand the genomic identification of different strains, antimicrobial resistance patterns, and epidemiological typing of organisms, whole\u2010genome sequencing (WGS) analysis provides insight to explore new epitopes to develop new drugs against the organism. Therefore, the study is aimed at investigating the whole genome sequence of <jats:italic>A. baumannii<\/jats:italic> strains to report the new intensifications in its genomic profile. The genome sequences were retrieved from the NCBI database system. Pan\u2010genome BPGA (Bacterial Pan\u2010genome Analysis Tool) was used to analyze the core, pan, and species\u2010specific genome analysis. The pan and core genome curves were extrapolated using the empirical power law equation <jats:italic>f<\/jats:italic>(<jats:italic>x<\/jats:italic>) = <jats:italic>a<\/jats:italic>.<jats:italic>x<\/jats:italic><jats:italic>b<\/jats:italic> and the exponential equation <jats:italic>f<\/jats:italic>1(<jats:italic>x<\/jats:italic>) = <jats:italic>c<\/jats:italic>.<jats:italic>e<\/jats:italic>\u2009(<jats:italic>d<\/jats:italic>.<jats:italic>x<\/jats:italic>). To identify the resistant genes with resistant mutations against antibiotics, ResFinder and Galaxy Community hub bioinformatics tools were used. According to pan\u2010genome analysis, there were 2227 core genes present in each species of the <jats:italic>A. baumannii<\/jats:italic> genome. Furthermore, the number of accessory genes ranged from 1182 to 1460, and the unique genes in the genome were 931. There were 325 exclusively absent genes in the genome of <jats:italic>Acinetobacter baumannii.<\/jats:italic> The pan\u2010genome analysis showed that there is a 5\u2010fold increase in the genome of <jats:italic>A. baumannii<\/jats:italic> in 5 years, and the genome is still open. There is the addition of multiple unique genes; among them, genes participating in the function of information and processing are increased.<\/jats:p>","DOI":"10.1155\/2022\/3186343","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T01:50:08Z","timestamp":1672192208000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intensification in Genetic Information and Acquisition of Resistant Genes in Genome of <i>Acinetobacter baumannii<\/i>: A Pan\u2010Genomic Analysis"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3631-3001","authenticated-orcid":false,"given":"Akhtar","family":"Ali","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7749-7754","authenticated-orcid":false,"given":"Ambrina","family":"Khatoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-3966","authenticated-orcid":false,"given":"Talat","family":"Mirza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,27]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.2147\/IDR.S166750"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00055"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2016.02.009"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12941-016-0123-7"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v3i1.231"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/jam.14330"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.3390\/s120302519"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.12.013"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1099\/mgen.0.000339"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0218204"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2020.09.003"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-018-0437-7"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2020.00775"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijmm.2019.151339"},{"key":"e_1_2_8_15_2","unstructured":"ABRicate software 2022 https:\/\/github.com\/tseemann\/abricate."},{"key":"e_1_2_8_16_2","unstructured":"Res-finder 2022 Cited 2021.https:\/\/pubmed.ncbi.nlm.nih.gov\/22782487\/."},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3390\/antibiotics9040205"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13756-020-00872-w"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00840-20"},{"key":"e_1_2_8_20_2","first-page":"1823","article-title":"Biocides role in the selection and dissemination of resistant Acinetobacter baumannii clones","volume":"25","author":"Vrancianu C. 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