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Psoriasis is a common chronic inflammatory skin disease with multifactor etiology, characterized by abnormal proliferation and differentiation of keratinocytes. Huang-Lian Jie-Du decoction (HLJDD) is a traditional Chinese medicine prescription with good clinical curative effect on psoriasis. However, its therapeutic mechanisms are still unclear. Methods. The psoriasis model of SKH-1 nude mice was established by imiquimod-induced and HLJDD gavage was given. Hematoxylin and eosin staining were used to evaluate pathological morphologies, and immunohistochemistry was used to detect the expressions of Wnt1, \u03b2-catenin, and c-Myc in psoriasis mice. Western blot was used to examine the expressions of Frizzled-2, LRP5\/6, GSK-3\u03b2, APC, Axin2, TCF4, LEF1, cyclin D1, TBX3, EPHB2, and NOTUM enzyme. Results. In this study, HLJDD reduced skin erythema and lesions, decreased the thickness of epidermal and downregulated the expressions of Wnt1, \u03b2-catenin, and c-Myc. Western blot results showed that HLJDD reduced the expressions of Wnt receptors Frizzled-2 and LRP5\/6, and Wnt downstream target genes TCF4, LEF1, cyclin D1, TBX3, and EPHB2, while upregulated destruction complex proteins GSK-3\u03b2, APC, and Axin2. Conclusions. HLJDD can effectively treat psoriasis and inhibit the Wnt\/\u03b2-catenin signaling pathway at multiple stages.<\/jats:p>","DOI":"10.1155\/2022\/3193572","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T19:05:08Z","timestamp":1649963108000},"page":"1-11","source":"Crossref","is-referenced-by-count":2,"title":["Intervention Mechanism of Hunag-Lian Jie-Du Decoction on Canonical Wnt\/\u03b2-Catenin Signaling Pathway in Psoriasis Mouse Model"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3008-3807","authenticated-orcid":true,"given":"Xuesong","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology, The First Affiliated Hospital of Yunnan Traditional Chinese Medicine University, No. 120 Guanghua Rd, Kunming, Yunnan 650021, 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