{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:02:43Z","timestamp":1791820963017,"version":"4.3.4"},"reference-count":57,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T00:00:00Z","timestamp":1648684800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015656","name":"Jahrom University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015656","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pain Research and Management"],"published-print":{"date-parts":[[2022,3,31]]},"abstract":"<jats:p>Background. Migraine is one of the most common types of headache, and it is the second most common cause of neurological disorders, with an annual prevalence of about 15% of the population. This study aimed to evaluate the effect of BoNT-A on the duration and intensity of migraine attacks. In addition, we investigated the effective injection sites. Methods. According to the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines, we searched online databases, including Web of Science, PubMed, EMBASE, Scopus, Cochrane Library, ProQuest, ClinicalTrials.gov, and Google Scholar from 2011 to 2021. Results. A total of 24 articles were included in the study. The use of BoNT-A in individuals suffering from chronic migraine (CM) decreases the frequency of migraine attacks per month, pain intensity, medication use, emergency visits, and migraine-related disabilities. The BoNT-A was well tolerated and leads to improved performance and better quality of life (QoL). Overall, treatment with BoNT-A in adults with CM is beneficial. In addition, the use of BoNT-A in individuals with vestibular migraine (VM) reduces the frequency of migraines and brings about the improvement of disability status caused by migraine headaches. Meanwhile, the use of BoNT-A reduces the frequency of migraine attacks per month among individuals with chronic refractory migraine (CRM). Conclusions. The use of BoNT-A is a low-cost option for the treatment of various kinds of migraines, including chronic, episodic, unilateral, and vestibular types. BoNT-A can reduce the frequency of migraine attacks per month and diminish the severity of pain.<\/jats:p>","DOI":"10.1155\/2022\/3284446","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T01:22:57Z","timestamp":1648776177000},"page":"1-15","source":"Crossref","is-referenced-by-count":44,"title":["Botox (OnabotulinumtoxinA) for Treatment of Migraine Symptoms: A Systematic Review"],"prefix":"10.1155","volume":"2022","author":[{"given":"Negar","family":"Shaterian","sequence":"first","affiliation":[{"name":"Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"USERN Office, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Shaterian","sequence":"additional","affiliation":[{"name":"School of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aref","family":"Ghanaatpisheh","sequence":"additional","affiliation":[{"name":"Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"USERN Office, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Abbasi","sequence":"additional","affiliation":[{"name":"Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"USERN Office, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Daniali","sequence":"additional","affiliation":[{"name":"Student Research Committee, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"USERN Office, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3915-4205","authenticated-orcid":true,"given":"Maryam Jalali","family":"Jahromi","sequence":"additional","affiliation":[{"name":"Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"Department of Internal Medicine, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8437-1092","authenticated-orcid":true,"given":"Mohammad Sadegh","family":"Sanie","sequence":"additional","affiliation":[{"name":"Research Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran"},{"name":"Department of Anesthesia and Intensive Care, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4326-4586","authenticated-orcid":true,"given":"Amir","family":"Abdoli","sequence":"additional","affiliation":[{"name":"Zoonoses Research Center, Jahrom University of Medical Sciences, Jahrom, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-318254"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.40061"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3988\/jcn.2021.17.1.77"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2018.12.004"},{"issue":"5","key":"5","first-page":"930","article-title":"Serum levels of endocan, claudin-5 and cytokines in migraine","volume":"20","author":"M. 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