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The purpose of this paper was to study the effect of electroacupuncture (EA) on choroidal blood flow (ChBF) in a guinea pig model of lens-induced myopia (LIM). Methods. Guinea pigs were randomly divided into 4 groups: normal control (NC) group, LIM group, LIM\u2009+\u2009electroacupuncture (LIM\u2009+\u2009EA) group, and LIM\u2009+\u2009sham acupoint (LIM\u2009+\u2009sham) group. Right eyes were covered with a \u22126D lens to induce myopia. Meanwhile, LIM\u2009+\u2009EA group and LIM\u2009+\u2009sham group were treated with EA at acupoints Hegu (LI4) and Taiyang (EX-HN5) and sham points. Refraction, axial length (AL), choroidal thickness (ChT), vessel density of choriocapillaris (CC) and choroidal layer, and scleral collagen fiber were measured. Besides, hypoxia-inducible factor-1\u03b1 (HIF-1\u03b1), matrix metalloprotein-2 (MMP-2), and tissue inhibitor metalloprotease-2 (TIMP-2) expression in sclera were detected. Results. Refraction and AL were significantly decreased and ChT and vessel density of CC were significantly increased in LIM\u2009+\u2009EA group at 2 weeks and 4 weeks (all<jats:inline-formula><a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\"><a:mi>P<\/a:mi><a:mo>&lt;<\/a:mo><a:mn>0.05<\/a:mn><\/a:math><\/jats:inline-formula>) compared with LIM group. However, no significant difference of vessel density of choroidal layer was observed between LIM and LIM\u2009+\u2009EA group at 2 weeks and 4 weeks. Scleral collagen fibrils diameters were significantly increased in LIM\u2009+\u2009EA group at 4 weeks (<jats:inline-formula><c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\"><c:mi>P<\/c:mi><c:mo>&lt;<\/c:mo><c:mn>0.001<\/c:mn><\/c:math><\/jats:inline-formula>) compared with LIM group. At the end of experiment, the mRNA and protein expression of HIF-1\u03b1 and MMP-2 were significantly decreased (all<jats:inline-formula><e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\"><e:mi>P<\/e:mi><e:mo>&lt;<\/e:mo><e:mn>0.05<\/e:mn><\/e:math><\/jats:inline-formula>) and those of TIMP-2 were increased in LIM\u2009+\u2009EA, compared with LIM. However, there were no significant differences between LIM and LIM\u2009+\u2009sham group. Conclusions. EA can improve the vessel density of choroid and then possibly improve scleral hypoxia, which may inhibit the growth of the AL in myopia guinea pig.<\/jats:p>","DOI":"10.1155\/2022\/3286583","type":"journal-article","created":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T19:50:10Z","timestamp":1656100210000},"page":"1-11","source":"Crossref","is-referenced-by-count":6,"title":["Electroacupuncture Improves Choroidal Blood Flow to Inhibit the Development of Lens-Induced Myopia in Guinea Pigs"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0234-7062","authenticated-orcid":true,"given":"Ting","family":"Yu","sequence":"first","affiliation":[{"name":"Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan 250014, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Xie","sequence":"additional","affiliation":[{"name":"Affiliated Eye Hospital of Shandong University of Traditional 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University of Traditional Chinese Medicine, No. 48, Yingxiongshan Road, Jinan 250002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingmei","family":"Tian","sequence":"additional","affiliation":[{"name":"Affiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, No. 48, Yingxiongshan Road, Jinan 250002, China"},{"name":"Shandong Provincial Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Therapy of Ocular Diseases, Key Laboratory of Integrated Traditional Chinese and WesternMedicine for Prevention and Therapy of Ocular Diseases in Universities of Shandong, Eye Institute of Shandong University of Traditional Chinese Medicine, No. 48, Yingxiongshan Road, Jinan 250002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7045-728X","authenticated-orcid":true,"given":"Jike","family":"Song","sequence":"additional","affiliation":[{"name":"Shandong University 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