{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:21:44Z","timestamp":1788517304993,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Anesthesiology"],"published-print":{"date-parts":[[2022,3,11]]},"abstract":"<jats:p>During the recent COVID-19 pandemic, the rapidly progressive shortage of intravenous sedative drugs led numerous intensive care units to look for potential alternatives in patients requiring mechanical ventilation for severe acute respiratory distress syndrome (ARDS). Inhalational sedation using the AnaConDa\u00ae device for sevoflurane administration is a possible option. In a 54-year-old COVID-19 patient with severe ARDS requiring extracorporeal membranous oxygenation (ECMO), sevoflurane on AnaConDa\u00ae device was administered for 8\u2009days but was complicated by the development of nephrogenic diabetes insipidus (NDI). Other causes of NDI or central diabetes insipidus were reasonably excluded, as in other previously published cases of NDI in ICU patients receiving prolonged sevoflurane-based sedation. In addition, the postmortem examination suggested a lower expression of aquaporin-2 in renal tubules. This observation should prompt further investigations to elucidate the role of aquaporin-2 in sevoflurane-related NDI. Inhaled isoflurane sedation is a possible alternative.<\/jats:p>","DOI":"10.1155\/2022\/3312306","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T22:20:11Z","timestamp":1647037211000},"page":"1-4","source":"Crossref","is-referenced-by-count":9,"title":["Nephrogenic Diabetes Insipidus following an Off-Label Administration of Sevoflurane for Prolonged Sedation in a COVID-19 Patient and Possible Influence on Aquaporin-2 Renal Expression"],"prefix":"10.1155","volume":"2022","author":[{"given":"Camie","family":"Dupuis","sequence":"first","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Robert","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludovic","family":"Gerard","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johann","family":"Morelle","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Laterre","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4409-3352","authenticated-orcid":true,"given":"Philippe","family":"Hantson","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Cliniques Universitaires St-Luc, Universit\u00e9 Catholique de Louvain, Brussels, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-020-06154-8"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199651040-00009"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3109\/14017431.2012.676209"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000001634"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1007\/s00134-011-2187-3"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0b013e3181a1988b"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/ccm.0000000000001956"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1213\/xaa.0000000000000871"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2020.07.019"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1213\/00000539-199710000-00041"},{"issue":"1","key":"11","first-page":"47","article-title":"Polyuria with sevoflurane administration: a case report","volume":"79","author":"L. 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