{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:06:57Z","timestamp":1773328017207,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Hematology"],"published-print":{"date-parts":[[2022,12,28]]},"abstract":"<jats:p>The majority of patients with acute myeloid leukemia (AML) with the NPM1 mutation achieve remission with intensive chemotherapy. However, many patients subsequently relapse, which occurs frequently within the first 2\u20133\u2009years after therapy, while late relapse after more than 10\u2009years is rare and can also represent secondary\/therapy-associated AML without the NPM1 mutation. Here, we present a case of NPM1-mutated AML that developed medullary and extramedullary relapse 17\u2009years after allogeneic stem cell transplantation, maintaining the NPM1 mutation and all other genetic alterations detected at first diagnosis. This exceptionally long latency between diagnosis and relapse of a genetically highly related leukemic clone implies the existence of therapy-resistant, persisting dormant leukemic stem cells in NPM1 mutant AML.<\/jats:p>","DOI":"10.1155\/2022\/3317936","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T19:20:16Z","timestamp":1672255216000},"page":"1-3","source":"Crossref","is-referenced-by-count":1,"title":["Relapse of NPM1-Mutated AML with Extramedullary Manifestation 17\u2009Years after Allogeneic Hematopoietic Stem Cell Transplantation"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2026-2641","authenticated-orcid":true,"given":"Jan","family":"Braune","sequence":"first","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathrin","family":"Rieger","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4304-5079","authenticated-orcid":true,"given":"Olga","family":"Blau","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8485-1958","authenticated-orcid":true,"given":"Ulrich","family":"Keller","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5890-5510","authenticated-orcid":true,"given":"Lars","family":"Bullinger","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kr\u00f6nke","sequence":"additional","affiliation":[{"name":"Department of Hematology, Oncology and Cancer Immunology, Charit\u00e9-Universit\u00e4tsmedizin Berlin, Freie Universit\u00e4t Berlin and Humboldt-Universit\u00e4t zu Berlin, Berlin, Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site Berlin and German Cancer Research Center (DKFZ), Heidelberg, Germany"},{"name":"Berlin Institute of Health (BIH), Berlin, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1406184"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2014.05.018"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1080\/10428194.2019.1706733"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13245"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(06)70661-1"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24009"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000001989"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09745-2"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-01-479188"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2016.04.001"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1038\/nature13968"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2016.44"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1038\/s43018-020-0088-5"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-018-0249-2"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.03.025"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2018.08.007"}],"container-title":["Case Reports in Hematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/3317936.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/3317936.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/crihem\/2022\/3317936.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T19:20:19Z","timestamp":1672255219000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/crihem\/2022\/3317936\/"}},"subtitle":[],"editor":[{"given":"H\u00e5kon","family":"Reikvam","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,12,28]]},"references-count":16,"alternative-id":["3317936","3317936"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3317936","relation":{},"ISSN":["2090-6579","2090-6560"],"issn-type":[{"value":"2090-6579","type":"electronic"},{"value":"2090-6560","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12,28]]}}}