{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T08:11:56Z","timestamp":1767168716298,"version":"build-2238731810"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T00:00:00Z","timestamp":1657584000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ala PDT (Photodynamic) Combined with 1550 Point Needle Nano Laser in the Treatment of Rose Acne","award":["2019-124"],"award-info":[{"award-number":["2019-124"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,7,12]]},"abstract":"\n Objective. To explore the clinical effect and safety of 5-aminolevulinic acid photodynamic therapy (ALA-PDT) combined with 1550\u2009nm fractional laser therapy in the treatment of rosacea. Methods. 114 patients with type I and type II rosacea treated in our hospital from March 2018 to April 2020 were recruited. They were randomly assigned (1\u2009:\u20091\u2009:\u20091) to receive ALA-PDT (photodynamic group), 1550\u2009nm fractional laser (laser group), or ALA-PDT and 1550\u2009nm fractional laser therapy (combination group). Outcome measures included skin lesion scores, efficacy, and adverse reactions. Results. After treatment, patients in the three groups showed lower skin lesion scores than before treatment, and the combination group showed significantly lower results than the other groups (\n \n \n P<\/a:mi>\n <<\/a:mo>\n 0.05<\/a:mn>\n <\/a:math>\n <\/jats:inline-formula>\n ). There was no significant difference in the total efficacy among the three groups (\n \n \n P<\/c:mi>\n ><\/c:mo>\n 0.05<\/c:mn>\n <\/c:math>\n <\/jats:inline-formula>\n ), but the combination group outperformed the other groups in the comparison of the efficacy levels (\n \n \n P<\/e:mi>\n <<\/e:mo>\n 0.05<\/e:mn>\n <\/e:math>\n <\/jats:inline-formula>\n ). Edema with lupus erythematosus, pain, and burning sensation was found in some cases but disappeared within 2 to 4 days after symptomatic treatment without interference with subsequent treatment. No patients had pigmentation, hypopigmentation, scars, or other serious adverse reactions. Conclusion. In the treatment of rosacea, ALA-PDT combined with a 1550\u2009nm fractional laser can reduce redness and facilitate skin remodeling, with high efficacy and safety, so it is worthy of clinical promotion and application.\n <\/jats:p>","DOI":"10.1155\/2022\/3335074","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T19:35:05Z","timestamp":1657654505000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Effect and Safety of ALA-PDT Combined with 1550\u2009nm Fractional Therapy Laser in Treating Rosacea"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hefei","family":"Wang","sequence":"first","affiliation":[{"name":"Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoxia","family":"An","sequence":"additional","affiliation":[{"name":"Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-3370","authenticated-orcid":true,"given":"Zhengli","family":"Wang","sequence":"additional","affiliation":[{"name":"Heilongjiang Provincial Hospital, Harbin, Heilongjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"issue":"10","key":"1","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/1346-8138.15478","article-title":"Use of proton pump inhibitors and risk of rosacea: a nationwide population\u2010based study","volume":"47","author":"Y.-X. Dai","year":"2020","journal-title":"The Journal of Dermatology"},{"issue":"6","key":"2","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1016\/j.jaad.2020.01.077","article-title":"Standard management options for rosacea: the 2019 update by the national rosacea society expert committee","volume":"82","author":"D. Thiboutot","year":"2020","journal-title":"Journal of the American Academy of Dermatology"},{"issue":"6","key":"3","first-page":"42","article-title":"Clinical effect and nursing care of rosacea treated by photon rejuvenation technology","volume":"25","author":"H. Hu","year":"2018","journal-title":"Contemporary Nurses (Zhongxunjian)"},{"issue":"6","key":"4","first-page":"e175","article-title":"Rosacea: a wholistic review and update from pathogenesis to diagnosis and therapy","volume":"59","author":"W. 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