{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T02:07:10Z","timestamp":1792634830106,"version":"4.5.0"},"reference-count":90,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T00:00:00Z","timestamp":1641513600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004960","name":"Universidad Aut\u00f3noma del Estado de M\u00e9xico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004960","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Food Science"],"published-print":{"date-parts":[[2022,1,7]]},"abstract":"<jats:p>Introduction. The effects of fatty acids on health vary and depend on the type, amount, and route of consumption. EPA and DHA have a defined role in health, unlike coconut oil. Objective. The aim was to investigate the changes in metabolic regulation and the composition of the culture-dependent microbiota after supplementation with different fatty acids in db\/db mice. Material and Methods. We were using 32 8-week-old db\/db mice, supplemented for eight weeks with EPA\/DHA derived from microalgae as well as coconut oil. The lipid, hormonal profiles, and composition of the culture-dependent microbiota and the phylogenetic analysis based on the 16S rRNA gene sequencing were determined for identification of the intestinal microbiota. Results. Enriched diet with EPA\/DHA reduced TNF-\u03b1, C-peptide, insulin resistance, resistin, and the plasma atherogenic index, but increased TC, LDL-c, VLDL-c, and TG without changes in HDL-c. Coconut oil raised the HDL-c, GIP, and TNF-\u03b1, with TG, insulin resistance, adiponectin, and C-peptide reduced. Conclusion. The most abundant microbial populations were Firmicutes and the least Proteobacteria. EPA\/DHA derived from microalgae contributes to improving the systemic inflammatory status, but depressed the diversity of the small intestine microbiota. Coconut oil only decreased the C-peptide, raising TNF-\u03b1, with an unfavorable hormonal and lipid profile.<\/jats:p>","DOI":"10.1155\/2022\/3336941","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T21:35:21Z","timestamp":1641591321000},"page":"1-14","source":"Crossref","is-referenced-by-count":4,"title":["Changes in Metabolic Regulation and the Microbiota Composition after Supplementation with Different Fatty Acids in db\/db Mice"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2663-5202","authenticated-orcid":true,"given":"Beatriz Elina","family":"Mart\u00ednez-Carrillo","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan, Esquina Jes\u00fas Carranza, s\/n, Colonia Moderna de la Cruz, C.P, 50180 Toluca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7009-5998","authenticated-orcid":true,"given":"Talia","family":"Mondrag\u00f3n-Vel\u00e1squez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan, Esquina Jes\u00fas Carranza, s\/n, Colonia Moderna de la Cruz, C.P, 50180 Toluca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3108-895X","authenticated-orcid":true,"given":"Ninfa","family":"Ram\u00edrez-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Laboratorio de Microbiolog\u00eda M\u00e9dica y Ambiental, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan, Esquina Jes\u00fas Carranza, s\/n, Colonia Moderna de la Cruz, C.P, 50180 Toluca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4017-3753","authenticated-orcid":true,"given":"Jos\u00e9 F\u00e9lix","family":"Aguirre-Garrido","sequence":"additional","affiliation":[{"name":"Laboratorio de Biotecnolog\u00eda Ambiental, Departamento de Ciencias Ambientales, Universidad Aut\u00f3noma Metropolitana, Unidad Lerma, Lerma de Villada, Estado de M\u00e9xico, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0093-886X","authenticated-orcid":true,"given":"Roxana","family":"Vald\u00e9s-Ramos","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan, Esquina Jes\u00fas Carranza, s\/n, Colonia Moderna de la Cruz, C.P, 50180 Toluca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0294-2515","authenticated-orcid":true,"given":"Ana Laura","family":"Guadarrama-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Nutrici\u00f3n, Facultad de Medicina, Universidad Aut\u00f3noma del Estado de M\u00e9xico, Paseo Tollocan, Esquina Jes\u00fas Carranza, s\/n, Colonia Moderna de la Cruz, C.P, 50180 Toluca, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4319-8849","authenticated-orcid":true,"given":"Arturo","family":"Castillo-Cardiel","sequence":"additional","affiliation":[{"name":"Departamento de Cirug\u00eda Experimental, Universidad Quetzalco\u00e1tl de Irapuato, Blvd. Arandas No. 975 Colonia Tabachines, C.P. 36715, Irapuato, Guanajuato, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12673"},{"key":"2","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.2741\/3074","article-title":"The implication of proinflammatory cytokines in type 2 diabetes","volume":"13","author":"C. 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