{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:27:38Z","timestamp":1787909258817,"version":"build-2784847793"},"reference-count":25,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,5,29]]},"abstract":"<jats:p>\n                    The study is aimed at evaluating corneal epithelial thickness changes associated with overnight orthokeratology (ortho-K). In this retrospective study, epithelial thickness was measured using optical coherence tomography (OCT) before and after 1 day, 1 week, 1 month, and 3 months ortho-K nightly lens wear. Compared with pre-orthokeratology measurements, central (2\u2009mm) corneal epithelium thickness was significantly reduced at 1 day, 1 week, 1 month, and 3 months with ortho-K (\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    ). Paracentral (2\u2009mm~5\u2009mm annular ring) epithelial thickness was also significantly reduced at superior temporal, inferior temporal, temporal, and inferior locations after ortho-K (\n                    <jats:inline-formula>\n                      <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                      <\/c:math>\n                    <\/jats:inline-formula>\n                    ), while midperipheral (5\u2009mm~6\u2009mm annular ring) epithelial thickness was greater post- than pre-ortho-K at superior, superior temporal, inferior temporal, inferior, and inferior nasal locations (\n                    <jats:inline-formula>\n                      <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                      <\/e:math>\n                    <\/jats:inline-formula>\n                    ). In other zones, superior, superior nasal, nasal, and inferior nasal in paracentral annular ring and temporal and superior nasal in midperipheral ring, epithelial thickness underwent no significant change. Ortho-K lens wear caused the central corneal epitheliums to thin. The temporal half zones become thinner in paracentral zones and thicker in midperipheral zones.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3361172","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:50:15Z","timestamp":1653871815000},"page":"1-5","source":"Crossref","is-referenced-by-count":6,"title":["Post-Ortho-K Corneal Epithelium Changes in Myopic Eyes"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2933-5413","authenticated-orcid":true,"given":"Dongyi","family":"Qu","sequence":"first","affiliation":[{"name":"Beijing AIER Fukang Eye Hospital, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuehua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Ming Vision Eye Clinic, Beijing, China"},{"name":"Ineye Hospital of Chengdu University of TCM, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10565"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.02-0680"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4748"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8d56"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0203652"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2020.02.015"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000001508"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1111\/cxo.12839"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2013.02.012"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12527"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1080\/02713680590907256"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-8005"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.151365"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e31820f16fb"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0b013e3181d951f7"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31820009bc"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.593723"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.03-0239"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10263"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-020-01477-y"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.1016\/S0886-3350(02)01512-2"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcrs.2004.10.026"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)71167-5"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(88)33179-9"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.1097\/OPX.0000000000000039"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3361172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3361172.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3361172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T00:50:18Z","timestamp":1653871818000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/3361172\/"}},"subtitle":[],"editor":[{"given":"Pei-Wen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,29]]},"references-count":25,"alternative-id":["3361172","3361172"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3361172","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"value":"1875-8630","type":"electronic"},{"value":"0278-0240","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,29]]}}}