{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T23:33:14Z","timestamp":1789687994827,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T00:00:00Z","timestamp":1648857600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["International Journal of Hepatology"],"published-print":{"date-parts":[[2022,4,2]]},"abstract":"<jats:p>Background. To evaluate the relationship between prognosticators representing tumor aggressiveness and socio-demographic, laboratory, and imaging findings in patients with hepatocellular carcinoma (HCC). Methods. We retrospectively searched patients with HCC between January 2017 and December 2019 in our tertiary referral hospital. The tumor-related factors and liver damage indicators and their relationship to indicate the value of prognosis were analyzed. Results. A total of 268 HCC patients, with a male-to-female ratio of 2.8\u2009:\u20091. The mean age was 52.6 years. The patient with portal vein thrombosis (PVT) was older, had higher liver laboratory parameters (AST, ALT, total bilirubin, and direct bilirubin), and had larger tumor size. Patients with the larger tumor size had a higher AFP level, had more tumor multifocality. The majority of patients were in Child\u2019s A (73.6%) and B (17.2%) classes. The laboratory parameters of HCC patients were increased in Child\u2019s C compared to other groups of Child-Pugh classification. Conclusions. The presence of PVT and large-sized tumor in patients with HCC indicated a poorer prognosis than non-PVT group and small tumor sizes.<\/jats:p>","DOI":"10.1155\/2022\/3370992","type":"journal-article","created":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T16:50:07Z","timestamp":1648918207000},"page":"1-7","source":"Crossref","is-referenced-by-count":5,"title":["Clinical Characteristics of Patients with Hepatocellular Carcinoma: A Single-Center 3-Year Experience from Somalia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2304-6135","authenticated-orcid":true,"given":"Mohamed A.","family":"Hassan-Kadle","sequence":"first","affiliation":[{"name":"SomGastro Clinic Center for Digestive and Liver Disease, College of Medicine and Health Science, Abrar University, Mogadishu, Somalia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian Muse","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Health Sciences Turkey, Mogadishu Somalia-Turkey Recep Tayyip Erdo\u011fan Training and Research Hospital, Mogadishu, Somalia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8099-8883","authenticated-orcid":true,"given":"Esra","family":"Keles","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, University of Health Sciences Turkey, Zeynep Kamil Training and Research Hospital, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9053-0835","authenticated-orcid":true,"given":"Hasan Huseyin","family":"Eker","sequence":"additional","affiliation":[{"name":"Department of Public Health, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2785-0406","authenticated-orcid":true,"given":"Kursad Nuri","family":"Baydili","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, University of Health Sciences Turkey, Hamidiye Faculty of Medicine, Istanbul 34668, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-3255","authenticated-orcid":true,"given":"Hussein Mahdi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences Turkey, Mogadishu Somalia-Turkey Recep Tayyip Erdo\u011fan Training and Research Hospital, Mogadishu, Somalia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5287-6061","authenticated-orcid":true,"given":"Abdirahman Abdikadir","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Health Sciences Turkey, Mogadishu Somalia-Turkey Recep Tayyip Erdo\u011fan Training and Research Hospital, Mogadishu, Somalia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1713263"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-019-0145-7"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i20.5935"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15069422"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1159\/000444394"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2008.05487.x"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1007\/s004320050189"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i12.3462"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1002\/jso.24099"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S177663"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v5.i6.311"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1016\/S1665-2681(19)31354-7"},{"key":"14","unstructured":"KadleM.HassanA. M.YasinA. M.SheikhA. H.OmarM. S.SayidA. M.Frequency of Hepatocellular Carcinoma and Its Associated of Hepatitis B and C in Patients Attending Mogadishu Hospitals. MBChB thesis2012Benadir University, SomaliaFaculty of Medicine and Surgery"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.36.43.21085"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.4103\/sajc.sajc_82_17"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-014-3510-3"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2014.03.006"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/3120185"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1159\/000484564"},{"issue":"3","key":"21","first-page":"127","article-title":"Major risk factors, clinical and laboratory characteristics of patients with hepatocellular carcinoma; a retrospective study at Tikur Anbassa hospital, Addis Ababa university, Addis Ababa, Ethiopia","volume":"53","author":"H. D. 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