{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:20:49Z","timestamp":1790792449083,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T00:00:00Z","timestamp":1649808000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Healthcare Engineering"],"published-print":{"date-parts":[[2022,4,13]]},"abstract":"<jats:p>In order to investigate the expression levels of serum IFN-\u03b3, IL-4, and tumor necrosis TNF-\u03b1 in patients with cervicitis complicated with human papillomavirus (HPV) infection and clinical significance, a retrospective study was conducted on 90 patients with chronic cervicitis complicated by HP V infection who visited our hospital from June 2020 to June 2021, and they are included in the research group. According to the degree of HPV infection, the patients are divided into low-risk HPV type group (n\u2009=\u200965 cases) and high-risk HPV type group (n\u2009=\u200925 cases); 50 patients with cervicitis (without HPV infection) who received treatment in our hospital are selected as control group 1. Fifty healthy women who underwent physical examination are selected as the control group 2. The general data of the two groups of patients during hospitalization are collected, and HPV-DNA, IFN-\u03b3, IL-4, and TNF-\u03b1 are detected in all patients. For patients with cervicitis complicated by HPV infection, the IFN-indexes in the body are significantly decreased, IL-4 and TNF-\u03b1are significantly increased, and with the degree of HPV infection, IFN-\u03b3, IL-4, and TNF-\u03b1 have high diagnostic performance with HPV infection, and there is a significant correlation between the three, which can be used in cervicitis complicated with HPV infection. It is widely used in the early diagnosis and screening of infected patients.<\/jats:p>","DOI":"10.1155\/2022\/3374655","type":"journal-article","created":{"date-parts":[[2022,4,14]],"date-time":"2022-04-14T00:35:08Z","timestamp":1649896508000},"page":"1-6","source":"Crossref","is-referenced-by-count":4,"title":["Analysis of Serum Levels of IFN-\u03b3, IL-4, and TNF-\u03b1 in Patients with Cervicitis Complicated by HPV Infection and Their Clinical Significance"],"prefix":"10.1155","volume":"2022","author":[{"given":"Jingxia","family":"Li","sequence":"first","affiliation":[{"name":"Gynecology Department, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejun","family":"Liu","sequence":"additional","affiliation":[{"name":"Gynecology Department, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Song","sequence":"additional","affiliation":[{"name":"Gynecology Department, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenli","family":"Liu","sequence":"additional","affiliation":[{"name":"Gynecology Department, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liyuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Gynecology Department, Affiliated Hospital of Hebei University of Engineering, Handan 056000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-4538","authenticated-orcid":true,"given":"Shucheng","family":"Chen","sequence":"additional","affiliation":[{"name":"Gynecology Department, Fourth Affiliated Hospital of Hebei Medical University, Shijiazhuang 050000, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"issue":"12","key":"1","first-page":"1","article-title":"Detection of papillomavirus subtypes and other pathogens infection in patients with cervical cancer and analysis of serum inflammatory factor levels","volume":"13","author":"Y. 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