{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:52:42Z","timestamp":1767167562762,"version":"build-2238731810"},"reference-count":41,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T00:00:00Z","timestamp":1658275200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Military Medical Science Research Project","award":["16CXZ001"],"award-info":[{"award-number":["16CXZ001"]}]},{"name":"Military Medical Science Research Project","award":["81573774"],"award-info":[{"award-number":["81573774"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["16CXZ001"],"award-info":[{"award-number":["16CXZ001"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573774"],"award-info":[{"award-number":["81573774"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,20]]},"abstract":"<jats:p>\n                    Objective. To develop and authenticate a risk stratification framework and nomogram for ascertaining cancer-specific survival (CSS) among the pediatric brainstem gliomas. Methods. For patients less than 12 years, according to Surveillance, Epidemiology, and End Results (SEER), information from 1998 to 2016 is found in their databases. The survival outcomes, treatments, and demographic clinicopathologic conditions are scrutinized per the database validation, and training cohorts are divided and validated using multivariate Cox regression analysis. A nomogram was designed, and predominantly, the risk stratification conceptualization engaged selected tenets according to the multivariate analysis. The model\u2019s authenticity was substantiated through C-index measure and calibration curves. Results. There are 806 pediatric concerns of histologically concluded brainstem glioma in the research. According to multivariate analysis, age, grade, radiotherapy, and race (with\n                    <jats:inline-formula>\n                      <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                      <\/a:math>\n                    <\/jats:inline-formula>\n                    value &lt; 0.05) depicted independent prognostic variations of the pediatric gliomas. The nomogram\u2019s C-index was approximately 0.75 and an accompanied predictive capability for CSS. Conclusion. The nomogram constructed in this glioma\u2019s context is the primary predictor of using risk stratification. A combination of nomograms with the risk stratification mechanism assists clinicians in monitoring high-risk individuals and engage targeted accessory treatment.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3436631","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T19:50:38Z","timestamp":1658346638000},"page":"1-9","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of Cancer-Specific Survival of Brainstem Glioma in Children Based on Risk Stratification Model"],"prefix":"10.1155","volume":"2022","author":[{"given":"Kai","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China"},{"name":"Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingwei","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaowei","family":"Fei","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The First Affiliated Hospital of The Fourth Military Medical University, Xi\u2019an, Shaanxi, 710032, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lunshan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9354-0529","authenticated-orcid":true,"given":"Ruxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Sichuan Academy of Medical Sciences and Sichuan Provincial People\u2019s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0034-5872","authenticated-orcid":true,"given":"Minhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.3109\/0284186X.2012.754993"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0519-x"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2017.11.010"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-013-0346-3"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.08.017"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2938"},{"issue":"7","key":"7","first-page":"570","article-title":"2016 WHO central nervous system tumor classification summary","volume":"31","author":"C. 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