{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:33:49Z","timestamp":1791588829993,"version":"4.3.4"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":129,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002402","name":"Sun Yat-sen University","doi-asserted-by":"publisher","award":["ZSQYLCKYJJ202001"],"award-info":[{"award-number":["ZSQYLCKYJJ202001"]}],"id":[{"id":"10.13039\/501100002402","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515010567"],"award-info":[{"award-number":["2021A1515010567"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007162","name":"Guangdong Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2014A020221063"],"award-info":[{"award-number":["2014A020221063"]}],"id":[{"id":"10.13039\/501100007162","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81803816"],"award-info":[{"award-number":["81803816"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82074078"],"award-info":[{"award-number":["82074078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>\n                    Nonalcoholic fatty liver disease (NAFLD) has gradually become one of the most serious liver diseases threatening human health in the world. Currently, Chinese herbal medicine is a potentially important treatment option for NAFLD, and the development of effective Chinese herbal medicine has a good prospect. Previous studies have suggested that\n                    <jats:italic>Ficus hirta<\/jats:italic>\n                    Vahl. (FV) has various protective effects on the liver. In this study, we investigated the therapeutic outcomes of FV treatment for the liver disease and its underlying mechanism using HepG2 cell lines induced by palmitate (PA) and mouse model fed with high\u2010fat diet (HFD). FV mainly exerts pharmacological effects by mediating lipid metabolism and inflammation. During the lipid metabolism regulation process, CD36, SREBP\u20101, SCD1, PPAR\n                    <jats:italic>\u03b3<\/jats:italic>\n                    , ACOX1, and CPT1\n                    <jats:italic>\u03b1<\/jats:italic>\n                    are the key factors related to the healing effects of FV on NAFLD. During the inflammation process, the downregulation of IL\u20106, IL\u20101\n                    <jats:italic>\u03b2<\/jats:italic>\n                    , and TNF\u2010\n                    <jats:italic>\u03b1<\/jats:italic>\n                    is involved in alleviation of NAFLD. Furthermore, CD36 overexpression promotes lipid abnormal metabolism and inflammation in PA\u2010induced HepG2 cells, while CD36 knockdown and FV supplementation reverse these responses. In addition, FV also modulates gut microbiota composition, such as\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    ,\n                    <jats:italic>Faecalibaculum<\/jats:italic>\n                    , and\n                    <jats:italic>Butyricicoccus<\/jats:italic>\n                    in HFD\u2010fed mice. In summary, our findings demonstrated that FV exerted a beneficial preventive and therapeutic effect on NAFLD by improving lipid metabolism and inflammation as well as regulating the structure of gut microbiota, and therefore, FV may be a candidate for the treatment of NAFLD.\n                  <\/jats:p>","DOI":"10.1155\/2022\/3474723","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T17:05:05Z","timestamp":1652202305000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["<i>Ficus hirta<\/i>\n                    Vahl. Ameliorates Nonalcoholic Fatty Liver Disease through Regulating Lipid Metabolism and Gut Microbiota"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1883","authenticated-orcid":false,"given":"Ting","family":"Quan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-2524","authenticated-orcid":false,"given":"Fangyu","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9100-8918","authenticated-orcid":false,"given":"Huiyuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8920-0724","authenticated-orcid":false,"given":"Lina","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3332-8363","authenticated-orcid":false,"given":"Yuxuan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3882-3112","authenticated-orcid":false,"given":"Fan","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7119-5728","authenticated-orcid":false,"given":"Shijian","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5630-110X","authenticated-orcid":false,"given":"Benjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4346-7535","authenticated-orcid":false,"given":"Shasha","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"e_1_2_11_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.109"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2021.101109"},{"key":"e_1_2_11_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28985"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104657"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26695"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29465"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.10.033"},{"key":"e_1_2_11_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30251"},{"key":"e_1_2_11_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11906-018-0812-z"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.272re3"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00074.2008"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101591"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-020-08711-3"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.04.006"},{"key":"e_1_2_11_16_2","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.C093674"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2011.01.009"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.3390\/plants6040044"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1186\/1752-153X-7-115"},{"key":"e_1_2_11_20_2","first-page":"571","article-title":"Study on the antitussive and antiasthmatic effects of Radix Fici Hirtae","volume":"32","author":"Zhou T. 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