{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:52:00Z","timestamp":1792633920566,"version":"4.5.0"},"reference-count":55,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T00:00:00Z","timestamp":1663027200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174515"],"award-info":[{"award-number":["82174515"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Evidence-Based Complementary and Alternative Medicine"],"published-print":{"date-parts":[[2022,9,13]]},"abstract":"<jats:p>Objective. The goal was to investigate the connection between neuroinflammation in the brain and serum inflammatory markers as Alzheimer\u2019s disease progressed. We also sought to determine whether electroacupuncture had an effect on inflammatory markers found in blood and other brain regions. Methods. As an animal model for AD, we used senescence-accelerated mouse prone 8 (SAMP8) mice. To examine the effects and probable mechanism of electroacupuncture, we used HE staining, immunofluorescence staining, western blotting, and enzyme-linked immunosorbent assay. Results. Electroacupuncture therapy protected neurons, significantly downregulated the Iba-1 level in the hippocampus (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                     <\/a:math>\n                  <\/jats:inline-formula> value was 0.003), frontal lobe cortex (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                     <\/c:math>\n                  <\/jats:inline-formula> value was 0.042), and temporal lobe cortex (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                     <\/e:math>\n                  <\/jats:inline-formula> value was 0.013) of the AD animal model, all of which had significantly lower levels of IL-6 (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>p<\/g:mi>\n                     <\/g:math>\n                  <\/jats:inline-formula> value was 0.001), IL-1\u03b2 (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>p<\/i:mi>\n                     <\/i:math>\n                  <\/jats:inline-formula> value was 0.001), and TNF-\u03b1 (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                     <\/k:math>\n                  <\/jats:inline-formula> value was 0.001) in their serum. Conclusion. The amounts of IL-6, IL-1\u03b2, and TNF-\u03b1 detected in the serum were strongly linked to the levels discovered in the hippocampus and the frontal lobes of the brain, respectively. A better understanding of the electroacupuncture process as well as the course of Alzheimer\u2019s disease and the therapeutic benefits of electroacupuncture may be gained by using biomarkers such as serum inflammatory marker biomarkers.<\/jats:p>","DOI":"10.1155\/2022\/3478847","type":"journal-article","created":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T21:50:08Z","timestamp":1663105808000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Effects of Electroacupuncture on the Correlation between Serum and Central Immunity in AD Model Animals"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2731-4766","authenticated-orcid":true,"given":"Jing","family":"Jiang","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zidong","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruxia","family":"Yu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiling","family":"Tian","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shun","family":"Wang","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhigang","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine, School of Nursing, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoshu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Western Sydney University, School of Health Sciences, Sydney, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.12626"},{"key":"2","volume-title":"Alzheimer Disease. StatPearls. StatPearls Publishing Copyright \u00a9","author":"A. Kumar","year":"2020"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2019.112899"},{"issue":"4","key":"4","first-page":"1","article-title":"Neuroanatomy and pathology of sporadic alzheimer\u2019s disease neuroinflammation in alzheimer\u2019s disease: an understanding of physiology and pathology some evolutionary perspectives on alzheimer\u2019s disease pathogenesis and pathology","volume":"215","author":"H. Braak","year":"2015","journal-title":"Advances in Anatomy, Embryology, and Cell Biology"},{"issue":"2","key":"5","first-page":"179","article-title":"Physiology and pathology of tau protein kinases in relation to alzheimer\u2019s disease","volume":"121","author":"K. Imahori","year":"1997","journal-title":"Journal of Biochemistry"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2013.831852"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.1111\/imcb.12301"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.bj.2018.01.003"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00978"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12773"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/4430484"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2020.1496"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.3791\/60055"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1136\/acupmed-2016-011310"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/142129"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3131586"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8867547"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/3435891"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8296824"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21061989"},{"key":"21","article-title":"Cerebrospinal fluid amyloid beta, tau levels, apolipoprotein, and (1)H-MRS brain metabolites in alzheimer\u2019s disease: a systematic review","volume":"28","author":"A. D. Piersson","year":"2020","journal-title":"Academic Radiology"},{"key":"22","doi-asserted-by":"publisher","DOI":"10.3390\/jpm10030116"},{"key":"23","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5525710"},{"key":"24","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics11060984"},{"key":"25","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines8100421"},{"key":"26","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10050326"},{"key":"27","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2019.460717"},{"key":"28","doi-asserted-by":"publisher","DOI":"10.2174\/1567205017666201130092427"},{"key":"29","doi-asserted-by":"publisher","DOI":"10.1097\/wad.0000000000000342"},{"key":"30","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-018-1376-1"},{"key":"31","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-020-01806-4"},{"key":"32","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-316201"},{"key":"33","doi-asserted-by":"publisher","DOI":"10.1089\/acu.2021.0014"},{"key":"34","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-017-2064-x"},{"key":"35","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0196933"},{"key":"36","doi-asserted-by":"publisher","DOI":"10.1177\/02692155221079117"},{"key":"37","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00098"},{"key":"38","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.574023"},{"key":"39","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.689629"},{"key":"40","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1665-3"},{"key":"41","doi-asserted-by":"publisher","DOI":"10.3233\/jad-200242"},{"key":"42","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-020-00712-4"},{"key":"43","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.10.025"},{"key":"44","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00609"},{"issue":"3","key":"45","first-page":"1","article-title":"Dopaminergic neuronal death in the substantia nigra associates with change in serum levels of TNF-\u03b1 and IL-1\u03b2; evidence from early experimental model of parkinson\u2019s disease serum levels of hepcidin and interleukin 6 in parkinson\u2019s disease","volume":"80","author":"M. Sophiabadi","year":"2022","journal-title":"Neurological Research"},{"key":"46","doi-asserted-by":"publisher","DOI":"10.21307\/ane-2020-026"},{"key":"47","doi-asserted-by":"publisher","DOI":"10.3233\/jad-2010-101671"},{"key":"48","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2018.00606"},{"key":"49","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2701748"},{"key":"50","doi-asserted-by":"publisher","DOI":"10.14336\/ad.2020.0312"},{"key":"51","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2022.105684"},{"key":"52","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-020-01107-0"},{"key":"53","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-021-01339-8"},{"key":"54","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124539"},{"key":"55","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.317982"}],"container-title":["Evidence-Based Complementary and Alternative Medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/3478847.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/3478847.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/ecam\/2022\/3478847.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,13]],"date-time":"2022-09-13T21:50:16Z","timestamp":1663105816000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/ecam\/2022\/3478847\/"}},"subtitle":[],"editor":[{"given":"Weidong","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,13]]},"references-count":55,"alternative-id":["3478847","3478847"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3478847","relation":{},"ISSN":["1741-4288","1741-427X"],"issn-type":[{"value":"1741-4288","type":"electronic"},{"value":"1741-427X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9,13]]}}}