{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:35:36Z","timestamp":1768811736654,"version":"3.49.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":221,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Project of Regional Collaborative Innovation of Xinjiang Uygur Autonomous Region","award":["2022E01008"],"award-info":[{"award-number":["2022E01008"]}]},{"name":"Project of Regional Collaborative Innovation of Xinjiang Uygur Autonomous Region","award":["XJEDU2021I018"],"award-info":[{"award-number":["XJEDU2021I018"]}]},{"name":"Key Natural Science Projects of College Scientific Research Plan of Xinjiang Uygur Autonomous Region","award":["2022E01008"],"award-info":[{"award-number":["2022E01008"]}]},{"name":"Key Natural Science Projects of College Scientific Research Plan of Xinjiang Uygur Autonomous Region","award":["XJEDU2021I018"],"award-info":[{"award-number":["XJEDU2021I018"]}]},{"name":"2022 Graduate Scientific Research and Innovation Project of Xinjiang Uygur Autonomous Region","award":["2022E01008"],"award-info":[{"award-number":["2022E01008"]}]},{"name":"2022 Graduate Scientific Research and Innovation Project of Xinjiang Uygur Autonomous Region","award":["XJEDU2021I018"],"award-info":[{"award-number":["XJEDU2021I018"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Contrast Media &amp; Molecular Imaging"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Objective<\/jats:italic>. To analyze and test the effect of <jats:italic>Rhizoma phragmitis<\/jats:italic> and <jats:italic>Rhizoma curcumae<\/jats:italic> on the network pharmacology of MAPK (mitogen\u2010activated protein kinase) and TNF (tumor necrosis factor) signaling channels and inflammatory factor target gene regulation in successful modeling of chronic atrophic gastritis rats. <jats:italic>Methods<\/jats:italic>. Rats with chronic atrophic gastritis that were modeled successfully were randomly divided into control and study groups and were treated with conventional western medicine or Rhizoma phragmitis and Rhizoma curcumae, respectively. The pharmacological mechanism of action and efficacy were evaluated. <jats:italic>Results<\/jats:italic>. The treatment efficiency was 76.32% and 97.37% in the control and study group, respectively. After treatment, the serum tumor necrosis factor\u2010<jats:italic>\u03b1<\/jats:italic> (TNF\u2010<jats:italic>\u03b1<\/jats:italic>) and serum malondialdehyde (MDA) levels in the study group were lower than those in the control group and the serum epidermal growth factor (EGF) and superoxide dismutase (SOD) levels in the study group were higher than those in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); the pain behavioral scores in the study group were lower than those in the control group, and the free acid quantity and total acid quantity in the study group were higher than those in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); the serum MTL index in the study group was higher than that in the control group, and the serum gastrin (GAS) and pepsinogen I (PG I) indices in the study group were lower than those in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); the number of 24\u2010hour reflux in the study group was less than that in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05), and the longest reflux time in the study group was lower than that in the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). <jats:italic>Conclusion<\/jats:italic>. Based on the network pharmacological results, <jats:italic>Rhizoma phragmitis<\/jats:italic> and <jats:italic>Rhizoma curcumae<\/jats:italic> will modulate MAPK, TNF signaling circuits, and inflammatory factor target genes in the chronic atrophic gastritis rat model. This treatment protocol is efficient and beneficial to enhance the gastric function of the chronic atrophic gastritis rat model, while it can alleviate the inflammatory response and significantly reduce the number and duration of reflux, which is a safe and reliable treatment modality.<\/jats:p>","DOI":"10.1155\/2022\/3483774","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T15:50:18Z","timestamp":1660146618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Web\u2010Based Pharmacological Approach to the Mechanism of Action of Rhizoma Phragmitis and Rhizoma Curcumae in the Treatment of Chronic Atrophic Gastritis"],"prefix":"10.1155","volume":"2022","author":[{"given":"Yong","family":"Zhi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changming","family":"Shao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4348-0262","authenticated-orcid":false,"given":"Binfang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_8_1_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6693472"},{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiolchem.2021.107535"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118903"},{"key":"e_1_2_8_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114399"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v9.i35.10781"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.923327"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.06.021"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jpp\/rgaa065"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000022869"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000020374"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytochem.2020.112644"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5013"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.5129"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.113836"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/1534735420953215"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20200314.503"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5533946"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.658628"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114183"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021248"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20200916.401"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioorg.2021.105044"},{"key":"e_1_2_8_23_2","first-page":"18","article-title":"Network-based pharmacology to explore the mechanism of action of rhizoma curcumae longa-Huanglian medicine in the treatment of chronic atrophic gastritis[J]","volume":"62","author":"Jia Q. 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