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It is mainly characterized by fever, itching, encephalomyelitis, and respiratory and neurological disorders. <jats:italic>Plantago asiatica<\/jats:italic> polysaccharide (PLP), extracted from the whole plant of <jats:italic>Plantago asiatica<\/jats:italic> L., showed immunomodulatory and antioxidation effects, but the antiviral activity had not been reported. In this study, the inhibitory effect of PLP on PRV infection was studied. Our study first revealed that PLP could inhibit PRV infection in a dose\u2010dependent manner. By adding PLP at different stages of the virus\u2019s life cycle, we revealed that PLP could reduce the attachment and penetration of PRV into PK15 cells. The inhibition of PRV attachment was better than inhibition of PRV penetration. However, PLP did not affect PRV replication and inactivation. In addition, PLP decreased the intracellular ROS levels in infected cells significantly, and ROS scavenger NAC decreased PRV infection. 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