{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T13:08:54Z","timestamp":1792415334727,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Anemia"],"published-print":{"date-parts":[[2022,5,5]]},"abstract":"<jats:p>Background. \u03b2-Thalassemia has a very wide clinical variation, depending on the severity of the patient\u2019s condition. Individuals with \u03b2-thalassemia traits are usually asymptomatic; however, laboratory examination will show mild anemia with microcytic hypochromic erythrocytes morphology with wide variation depending on the genotype. This study was conducted to determine the reference value of hematological parameters and hemoglobin (Hb) analysis based on the phenotype of \u03b2-thalassemia (\u03b20 and \u03b2+) and determine the differences of hematological characteristics between the two phenotypes. Methods. This cross-sectional study was conducted by evaluating the hematological parameters and Hb analysis of the \u03b2-thalassemia trait in the family of thalassemia patient population. The subjects were divided into \u03b20 and \u03b2+. The subject with normal Hb analysis with or without iron deficiency was excluded. Results. A total of 203 subjects with thalassemia traits were included from the families of thalassemia patients, consisting of 101 subjects with \u03b20-thalassemia, 82 subjects with \u03b2+-thalassemia, and the mutation had not been found in 20 subjects. There was a relationship in the mean\/median of hematological parameters, HbA2 and HbF, between \u03b20-thalassemia and \u03b2+-thalassemia (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>). ROC for each hematological parameter, HbA2 and HbF, showed that the highest diagnostic value based on the area under the curve was mean corpuscular hemoglobin (MCH) (0.900) and mean corpuscular volume (MCV) (0.898). The cutoff point of MCH for \u03b20-thalassemia trait was \u226420.5\u2009pg (sensitivity 85%, specificity 90%) and MCV was \u226466.8\u2009fL (sensitivity 87%, specificity 87%). Conclusion. MCH values can be used as a screening tool for predicting \u03b20-thalassemia in the relatives of thalassemia patients in the South Sumatra population.<\/jats:p>","DOI":"10.1155\/2022\/3572986","type":"journal-article","created":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T18:35:36Z","timestamp":1651775736000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Hematological Parameters in Individuals with Beta Thalassemia Trait in South Sumatra, Indonesia"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-8683","authenticated-orcid":true,"given":"Dian Puspita","family":"Sari","sequence":"first","affiliation":[{"name":"Department of Child Health, Mohammad Hoesin Palembang Hospital, Palembang, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pustika Amalia","family":"Wahidiyat","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine University Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iswari","family":"Setianingsih","sequence":"additional","affiliation":[{"name":"Eijkman Institute for Molecular Biology, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ina S.","family":"Timan","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine University Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djajadiman","family":"Gatot","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine University Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aria","family":"Kekalih","sequence":"additional","affiliation":[{"name":"Department of Child Health, Faculty of Medicine University Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","reference":[{"key":"1","article-title":"2021 guidelines for the management of transfusion dependent thalassemia (tdt)","author":"M. D. Cappellini","year":"2021"},{"key":"2","volume-title":"Color Atlas of Clinical Hematology, Molecular and Cellular Basis of Disease","author":"A. V. Hoffbrand","year":"2019","edition":"5th"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.2471\/blt.06.036673"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13512"},{"key":"5","unstructured":"NilaiS.Hematologi dan analisis hemoglobin: suatu prediksi jenis mutasi thalassemia-\u03b2 pada populasi melayu di sumatera selatan2003Jakarta, IndonesiaUniversitas Indonesia"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1111\/ijlh.12527"},{"key":"7","volume-title":"Indonesia National Guidline for Management of Thalassemia","author":"Ministry of Health Indonesia","year":"2018"},{"key":"8","volume-title":"WHO Guideline on Use of Ferritin Concentrations to Assess Iron Status in Individuals and Population","author":"WHO","year":"2020"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011700"},{"key":"10","article-title":"Regional desk review of haemoglobinopathies with an emphasis on thalassaemia and accessibility and availability of safe blood and blood products as per these patients\u2019 requirement in south-east asia under universal health coverage","author":"World Health Organization","year":"2021"},{"issue":"Suppl 1","key":"11","first-page":"5","article-title":"Problems of genetic diseases and their services in Indonesia: a country report","volume":"26","author":"A. S. Sofro","year":"1995","journal-title":"The Southeast Asian Journal of Tropical Medicine and Public Health"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2020.1826327"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1097\/gim.0b013e3181cd68ed"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1007\/s13224-019-01220-8"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1163\/156855902320387961"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v79.1.238.238"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.4081\/hr.2018.7605"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.24293\/ijcpml.v25i3.1459"}],"container-title":["Anemia"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2022\/3572986.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2022\/3572986.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/anemia\/2022\/3572986.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T18:35:46Z","timestamp":1651775746000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/anemia\/2022\/3572986\/"}},"subtitle":[],"editor":[{"given":"Duran","family":"Canatan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":18,"alternative-id":["3572986","3572986"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3572986","relation":{},"ISSN":["2090-1275","2090-1267"],"issn-type":[{"value":"2090-1275","type":"electronic"},{"value":"2090-1267","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5,5]]}}}