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Mesenchymal stem cell\u2010derived exosomes (MSCs\u2010Exo) are enclosed by a lipid bilayer contain proteins, DNA, miRNA, and other components, which are important mediators of intercellular communication. It has been reported that exosomes could play an important role in the treatment of neurodegenerative diseases, nerve injury, and other neurological diseases. In this study, we examined the effects of MSCs\u2010Exo on dNCR aged mice after exploratory laparotomy and evaluated their potential regulatory mechanisms. We found that MSCs\u2010Exo treatment ameliorated cognitive impairment in dNCR aged mice. MSCs\u2010Exo inhibit hippocampus ferroptosis and increase the expression of silent information regulator 1 (SIRT1), factor nuclear factor\u2010erythroid 2\u2010related factor 2 (Nrf2), and heme oxygenase\u20101 (HO\u20101) in dNCR aged mice. Interestingly, the above effects of MSCs\u2010Exo on dNCR aged mice were abolished by SIRT1 selective inhibitor EX\u2010527. In conclusion, these findings indicated that MSCs\u2010Exo can ameliorate cognitive impairment by inhibiting hippocampus ferroptosis in dNCR aged mice via activating SIRT1\/Nrf2\/HO\u20101 signaling pathway, providing a potential avenue for the treatment of dNCR.<\/jats:p>","DOI":"10.1155\/2022\/3593294","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T01:50:26Z","timestamp":1664589026000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Mesenchymal Stem Cell\u2010Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1\/Nrf2\/HO\u20101 Signaling 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