{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:50:24Z","timestamp":1790650224056,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,30]],"date-time":"2022-09-30T00:00:00Z","timestamp":1664496000000},"content-version":"vor","delay-in-days":272,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81730053"],"award-info":[{"award-number":["81730053"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81330045"],"award-info":[{"award-number":["81330045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Oxidative Medicine and Cellular Longevity"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p>Neurological disorders are often progressive and lead to disabilities with limited available therapies. Epidemiological evidence implicated that prolonged exposure to hypoxia leads to neurological damage and a plethora of complications. Neural stem cells (NSCs) are a promising tool for neurological damage therapy in terms of their unique properties. However, the literature on the outcome of NSCs exposed to severe hypoxia is scarce. In this study, we identified a responsive gene that reacts to multiple cellular stresses, marked cold\u2010inducible RNA\u2010binding protein (CIRBP), which could attenuate NSC apoptosis under hypoxic pressure. Interestingly, ISRIB, a small\u2010molecule modulator of the PERK\u2010ATF4 signaling pathway, could prevent the reduction and apoptosis of NSCs in two steps: enhancing the expression of CIRBP through the protein kinase R\u2010 (PKR\u2010) like endoplasmic reticulum kinase (PERK) and activating transcription factor 4 (ATF4) axis. Taken together, CIRBP was found to be a critical factor that could protect NSCs against apoptosis induced by hypoxia, and ISRIB could be acted upstream of the axis and may be recruited as an open potential therapeutic strategy to prevent or treat hypoxia\u2010induced brain hazards.<\/jats:p>","DOI":"10.1155\/2022\/3627026","type":"journal-article","created":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T01:05:09Z","timestamp":1664586309000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["[Retracted] Resetting Proteostasis of CIRBP with ISRIB Suppresses Neural Stem Cell Apoptosis under Hypoxic Exposure"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-0007","authenticated-orcid":false,"given":"Yuankang","family":"Zou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyan","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maodeng","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhice","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruili","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Aschner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4826-3961","authenticated-orcid":false,"given":"Wenjing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5601-8547","authenticated-orcid":false,"given":"Jianbin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,30]]},"reference":[{"key":"e_1_2_10_1_2","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.643783"},{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12992-020-00654-4"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/jtm.12017"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.005"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygcen.2020.113473"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50770"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.03.030"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-021-00827-1"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2021.151228"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.156059"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2018.08.002"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-019-1597-y"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1374-y"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-31206-0_4"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2021.665821"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.1217726"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1261\/rna.076422.120"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-9761-1"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aat8406"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-39547-x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0250-z"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00212-1"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1839-z"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15073"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2020.10.031"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1815767116"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.aar5129"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2601-2"},{"key":"e_1_2_10_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2019.11.008"},{"key":"e_1_2_10_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.05.015"},{"key":"e_1_2_10_31_2","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.62048"},{"key":"e_1_2_10_32_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1707661114"},{"key":"e_1_2_10_33_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0436-0"},{"key":"e_1_2_10_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.03.047"},{"key":"e_1_2_10_35_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201801143"},{"key":"e_1_2_10_36_2","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-018-0894-x"},{"key":"e_1_2_10_37_2","doi-asserted-by":"publisher","DOI":"10.7150\/jca.38538"},{"key":"e_1_2_10_38_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12041-020-01247-1"},{"key":"e_1_2_10_39_2","first-page":"299","volume-title":"Methods in Molecular Biology","author":"Im K.","year":"2019"},{"key":"e_1_2_10_40_2","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-013-0046-5"},{"key":"e_1_2_10_41_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1017-9"},{"key":"e_1_2_10_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2016.05.011"},{"key":"e_1_2_10_43_2","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-52563-1"},{"key":"e_1_2_10_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.10.007"},{"key":"e_1_2_10_45_2","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00288"},{"key":"e_1_2_10_46_2","doi-asserted-by":"publisher","DOI":"10.14715\/cmb\/2017.63.7.2"},{"key":"e_1_2_10_47_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008575"},{"key":"e_1_2_10_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2019.02.011"},{"key":"e_1_2_10_49_2","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.020353"},{"key":"e_1_2_10_50_2","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy350"},{"key":"e_1_2_10_51_2","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6336"},{"key":"e_1_2_10_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-5149(02)00032-1"},{"key":"e_1_2_10_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.06.007"},{"key":"e_1_2_10_54_2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20181635"},{"key":"e_1_2_10_55_2","doi-asserted-by":"publisher","DOI":"10.1242\/jeb.01075"},{"key":"e_1_2_10_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1462"},{"key":"e_1_2_10_57_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2014.11.061"},{"key":"e_1_2_10_58_2","doi-asserted-by":"publisher","DOI":"10.1159\/000355242"},{"key":"e_1_2_10_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2015.07.004"},{"key":"e_1_2_10_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2015.01.002"},{"key":"e_1_2_10_61_2","doi-asserted-by":"publisher","DOI":"10.2174\/1566524016666160523143937"}],"updated-by":[{"DOI":"10.1155\/2023\/9838142","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"record-id":"58373"},{"DOI":"10.1155\/2023\/9838142","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000}}],"container-title":["Oxidative Medicine and Cellular Longevity"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/3627026.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/omcl\/2022\/3627026.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1155\/2022\/3627026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,3]],"date-time":"2025-06-03T00:54:20Z","timestamp":1748912060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1155\/2022\/3627026"}},"subtitle":[],"editor":[{"given":"Md Sayed","family":"Ali Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":61,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1155\/2022\/3627026"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3627026","archive":["Portico"],"relation":{"retraction":[{"id-type":"doi","id":"10.1155\/2023\/9838142","asserted-by":"object"}]},"ISSN":["1942-0900","1942-0994"],"issn-type":[{"value":"1942-0900","type":"print"},{"value":"1942-0994","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"2022-05-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-30","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"3627026"}}