{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T01:02:24Z","timestamp":1771462944952,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T00:00:00Z","timestamp":1657238400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Zhejiang TCM Science and Technology Plan","award":["2021ZA24"],"award-info":[{"award-number":["2021ZA24"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Computational and Mathematical Methods in Medicine"],"published-print":{"date-parts":[[2022,7,8]]},"abstract":"<jats:p>Objective. To investigate the effect of enhanced recovery after surgery (ERAS) with integrated traditional Chinese and Western medicine on postoperative stress response of patients suffering from gastrointestinal tumors. Methods. A total of 74 patients with gastrointestinal tumors who underwent surgical treatment in our hospital from April 2019 to March 2021 were recruited and randomized into the control group and the observation group (1\u2009:\u20091). The control group received routine treatment and care, while the observation group received ERAS plus integrated traditional Chinese and Western medicine. Clinical observation was performed regarding changes in preoperative mood and postoperative pain level in each group. Changes in expression levels of plasma cortisol, C-reactive protein (CRP), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumor necrosis factor-\u03b2 (TNF-\u03b2) before and after surgery were detected in each group. Time of patients\u2019 first fart and defecation and complications after surgery in each group were recorded. Results. The visual analogue scale (VAS) of patients in the observation group after 12 and 24\u2009h of surgery was significantly lower than that in the control group (12\u2009h: observation group 2.0 (1.00, 3.00) vs. control group 4.00 (3.00, 5.00), <jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>p<\/a:mi>\n                        <a:mo>=<\/a:mo>\n                        <a:mn>0.001<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>; 24\u2009h: observation group 2.00 (1.00, 3.00) vs. control group 3.00 (2.00, 5.00), <jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>p<\/c:mi>\n                        <c:mo>=<\/c:mo>\n                        <c:mn>0.005<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). The preoperative anxiety degree of patients in the two groups was not statistically significant (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>p<\/e:mi>\n                        <e:mo>=<\/e:mo>\n                        <e:mn>0.489<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>). The plasma cortisol level of patients in the observation group after 24 and 48\u2009h of surgery was significantly lower than that in the control group (24\u2009h: observation group <jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mn>426.54<\/g:mn>\n                        <g:mo>\u00b1<\/g:mo>\n                        <g:mn>52.15<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>\u2009nmol\/L vs. control group <jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mn>508.32<\/i:mn>\n                        <i:mo>\u00b1<\/i:mo>\n                        <i:mn>41.08<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>\u2009nmol\/L, <jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>p<\/k:mi>\n                        <k:mo>=<\/k:mo>\n                        <k:mn>0.001<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>; 48\u2009h: observation group <jats:inline-formula>\n                     <m:math xmlns:m=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M7\">\n                        <m:mn>287.19<\/m:mn>\n                        <m:mo>\u00b1<\/m:mo>\n                        <m:mn>44.24<\/m:mn>\n                     <\/m:math>\n                  <\/jats:inline-formula>\u2009nmol\/L vs. control group <jats:inline-formula>\n                     <o:math xmlns:o=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M8\">\n                        <o:mn>362.57<\/o:mn>\n                        <o:mo>\u00b1<\/o:mo>\n                        <o:mn>43.46<\/o:mn>\n                     <\/o:math>\n                  <\/jats:inline-formula>\u2009nmol\/L, <jats:inline-formula>\n                     <q:math xmlns:q=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M9\">\n                        <q:mi>p<\/q:mi>\n                        <q:mo>=<\/q:mo>\n                        <q:mn>0.001<\/q:mn>\n                     <\/q:math>\n                  <\/jats:inline-formula>). Patients\u2019 postoperative CRP, IL-6, IL-8, and TNF-\u03b2 expression levels in the observation group were remarkably lower than those in the control group at all time points. The first postoperative defecation came earlier in the observation group than that in the control group (observation group 76.00\u2009h (64.50, 87.50) vs. control group 89.00\u2009h (73.50, 116.00), <jats:inline-formula>\n                     <s:math xmlns:s=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M10\">\n                        <s:mi>p<\/s:mi>\n                        <s:mo>=<\/s:mo>\n                        <s:mn>0.007<\/s:mn>\n                     <\/s:math>\n                  <\/jats:inline-formula>). There was 1 postoperative urinary tract infection in the observation group and 1 postoperative intestinal obstruction and 1 incisional wound infection in the control group. Conclusion. ERAS with integrated traditional Chinese and Western medicine could effectively reduce the postoperative stress response and inflammatory reaction in patients with gastrointestinal tumors, contributing to the safe and quick recovery of gastrointestinal functions of patients.<\/jats:p>","DOI":"10.1155\/2022\/3663246","type":"journal-article","created":{"date-parts":[[2022,7,8]],"date-time":"2022-07-08T23:05:16Z","timestamp":1657321516000},"page":"1-8","source":"Crossref","is-referenced-by-count":10,"title":["Effect of Enhanced Recovery after Surgery with Integrated Traditional Chinese and Western Medicine on Postoperative Stress Response of Patients with Gastrointestinal Tumors"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7796-8939","authenticated-orcid":true,"given":"Haiping","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Fuyang, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2160-8010","authenticated-orcid":true,"given":"Wenhui","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of General Surgery, The First People\u2019s Hospital of Fuyang, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2019.09.026"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2017.00302"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-020-05333-z"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-019-6456-9"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-319915"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-017-0265-3"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v24.i1.76"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.5455\/medarh.2019.73.412-414"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2019.08.011"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1177\/0891988713495449"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.2460\/ajvr.78.8.919"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.1111\/codi.13643"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2016.4952"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(95)90643-6"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1089\/lap.2017.0317"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.1007\/s10120-019-00937-9"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-016-3460-y"},{"key":"18","article-title":"Effect of auricular plaster therapy combined with soothing touch on perioperative stress response of patients undergoing abdominal surgery","volume":"3","author":"S. 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