{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:03:24Z","timestamp":1740171804012,"version":"3.37.3"},"reference-count":21,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T00:00:00Z","timestamp":1663200000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008240","name":"Department of Health of Hebei Province","doi-asserted-by":"publisher","award":["1020140509"],"award-info":[{"award-number":["1020140509"]}],"id":[{"id":"10.13039\/501100008240","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Disease Markers"],"published-print":{"date-parts":[[2022,9,15]]},"abstract":"<jats:p>Objective. Tuberculous peritonitis (TP) can cause multiple infections of surrounding organs and tissues, leading to organ failure and endangering life safety. In this research, the relationship between adenosine deaminase (ADA), NLRP3 inflammasome, and TP and its clinical significance will be deeply explored, so as to provide new directions and reliable reference opinions for future clinical diagnosis and treatment. Methods. Altogether, 59 TP patients (research group, RG) and 52 non-TP patients (control group, CG) who were admitted to our hospital from May 2014 to June 2018 were regarded as research objects. Ascites samples of RG before treatment (admission) and one month after treatment and CG before treatment were obtained, and the ADA and NLRP3 levels were tested to evaluate the clinical and prognostic significance of the two in TP. Results. Before treatment, ADA and NLRP3 in RG were higher than CG (<jats:inline-formula>\n                     <a:math xmlns:a=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M1\">\n                        <a:mi>P<\/a:mi>\n                        <a:mo>&lt;<\/a:mo>\n                        <a:mn>0.05<\/a:mn>\n                     <\/a:math>\n                  <\/jats:inline-formula>), and the sensitivity and specificity of combined detection of the two in predicting TP occurrence were 89.83% and 73.08% (<jats:inline-formula>\n                     <c:math xmlns:c=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M2\">\n                        <c:mi>P<\/c:mi>\n                        <c:mo>&lt;<\/c:mo>\n                        <c:mn>0.05<\/c:mn>\n                     <\/c:math>\n                  <\/jats:inline-formula>). In addition, ADA and NLRP3 in RG patients were positively correlated with the disappearance time of abdominal pain and ascites (<jats:inline-formula>\n                     <e:math xmlns:e=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M3\">\n                        <e:mi>P<\/e:mi>\n                        <e:mo>&lt;<\/e:mo>\n                        <e:mn>0.05<\/e:mn>\n                     <\/e:math>\n                  <\/jats:inline-formula>) and had excellent predictive effect on the adverse reactions during treatment (<jats:inline-formula>\n                     <g:math xmlns:g=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M4\">\n                        <g:mi>P<\/g:mi>\n                        <g:mo>&lt;<\/g:mo>\n                        <g:mn>0.05<\/g:mn>\n                     <\/g:math>\n                  <\/jats:inline-formula>). After treatment, both in RG patients decreased, which was inversely proportional to the clinical efficacy (<jats:inline-formula>\n                     <i:math xmlns:i=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M5\">\n                        <i:mi>P<\/i:mi>\n                        <i:mo>&lt;<\/i:mo>\n                        <i:mn>0.05<\/i:mn>\n                     <\/i:math>\n                  <\/jats:inline-formula>). Prognostic follow-up manifested that ADA and NLRP3 in relapse patients were higher than those without recurrence after treatment (<jats:inline-formula>\n                     <k:math xmlns:k=\"http:\/\/www.w3.org\/1998\/Math\/MathML\" id=\"M6\">\n                        <k:mi>P<\/k:mi>\n                        <k:mo>&lt;<\/k:mo>\n                        <k:mn>0.05<\/k:mn>\n                     <\/k:math>\n                  <\/jats:inline-formula>). Conclusion. The increase of ADA and NLRP3 in TP is relevant to the adverse reactions during treatment, clinical efficacy, and prognosis recurrence after treatment. It can be used as a disease marker to confirm, intervene, and evaluate TP progression promptly.<\/jats:p>","DOI":"10.1155\/2022\/3664931","type":"journal-article","created":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T18:05:18Z","timestamp":1663265118000},"page":"1-8","source":"Crossref","is-referenced-by-count":2,"title":["Expression of Adenosine Deaminase and NLRP3 Inflammasome in Tuberculous Peritonitis and Their Relationship with Clinical Efficacy"],"prefix":"10.1155","volume":"2022","author":[{"given":"Hongwei","family":"Su","sequence":"first","affiliation":[{"name":"The Second Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050040, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guorong","family":"Yan","sequence":"additional","affiliation":[{"name":"The Second Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050040, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zijian","family":"Li","sequence":"additional","affiliation":[{"name":"The Second Department of Thoracic Surgery, Hebei Chest Hospital, Shijiazhuang 050040, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang 050040, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-5600","authenticated-orcid":true,"given":"Lingdi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hebei Chest Hospital, Shijiazhuang 050040, Hebei, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","doi-asserted-by":"publisher","DOI":"10.1128\/microbiolspec.TNMI7-0006-2016"},{"key":"2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMicm1713168"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3040"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.17116\/hirurgia201812138"},{"key":"5","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-245311"},{"key":"6","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2020.03.004"},{"key":"7","doi-asserted-by":"publisher","DOI":"10.4103\/ijmy.ijmy_68_20"},{"key":"8","doi-asserted-by":"publisher","DOI":"10.1016\/j.radcr.2019.09.026"},{"key":"9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2020.06.046"},{"key":"10","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-017-0433-3"},{"key":"11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0006515"},{"key":"12","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2013.36904"},{"key":"13","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2019102201"},{"key":"14","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.6854"},{"key":"15","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/2056168"},{"key":"16","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i37.5260"},{"key":"17","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00276"},{"key":"18","doi-asserted-by":"publisher","DOI":"10.1136\/gut.27.9.1049"},{"key":"19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2021.07.061"},{"key":"20","doi-asserted-by":"publisher","DOI":"10.1002\/cpim.107"},{"key":"21","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1701495"}],"container-title":["Disease Markers"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3664931.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3664931.xml","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/downloads.hindawi.com\/journals\/dm\/2022\/3664931.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T18:05:22Z","timestamp":1663265122000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.hindawi.com\/journals\/dm\/2022\/3664931\/"}},"subtitle":[],"editor":[{"given":"Yaoyao","family":"Bian","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2022,9,15]]},"references-count":21,"alternative-id":["3664931","3664931"],"URL":"https:\/\/doi.org\/10.1155\/2022\/3664931","relation":{},"ISSN":["1875-8630","0278-0240"],"issn-type":[{"type":"electronic","value":"1875-8630"},{"type":"print","value":"0278-0240"}],"subject":[],"published":{"date-parts":[[2022,9,15]]}}}