{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T10:12:21Z","timestamp":1771668741652,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Psychiatry"],"published-print":{"date-parts":[[2022,7,2]]},"abstract":"<jats:p>Evidence suggests that inhibition of protein kinase C (PKC) signalling may have a contributing role in the treatment of bipolar affective disorder (BPAD). Endoxifen, an active metabolite of tamoxifen, is a potent direct PKC inhibitor. This report presents a severe case of a BPAD patient with a baseline Young Mania Rating Scale (YMRS) score of 49, associated family history and addiction to psychostimulants, with no improvement by the first and second-generation antipsychotics. Treatment with endoxifen 8\u2009mg once a day showed improvement in manic symptoms with a YMRS score of 4 and a reduction in the use of psychostimulants as well as other antipsychotic concomitant medications. No adverse effects were noted up to 8-month follow-up. Long-term treatment with endoxifen is safe and effective in severe BPAD.<\/jats:p>","DOI":"10.1155\/2022\/3684181","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T15:05:08Z","timestamp":1656774308000},"page":"1-4","source":"Crossref","is-referenced-by-count":6,"title":["Real-World Long-Term Experience on Endoxifen in Bipolar Disorder with Psychotic Symptoms"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3799-8172","authenticated-orcid":true,"given":"Vikas","family":"Thanvi","sequence":"first","affiliation":[{"name":"Dr. Thanvi\u2019s Neuropsychiatry and Psychotherapy Centre, Jaipur, Rajasthan 302019, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","volume-title":"Manic-depressive illness: bipolar disorders and recurrent depression","author":"F. K. 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