{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:01:38Z","timestamp":1792839698721,"version":"4.5.0"},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":210,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["14JJ4015"],"award-info":[{"award-number":["14JJ4015"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970655"],"award-info":[{"award-number":["81970655"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81800664"],"award-info":[{"award-number":["81800664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070776"],"award-info":[{"award-number":["82070776"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900370"],"award-info":[{"award-number":["81900370"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["BioMed Research International"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:p><jats:italic>Background<\/jats:italic>. Owing to the advent of pangenotypic direct\u2010acting antiviral agents (DAAs) for hepatitis C virus (HCV) treatment, utilization of HCV\u2010infected deceased donor kidneys with simplified genotyping\/subtyping\u2010free sofosbuvir\/velpatasvir (SOF\/VEL) treatment strategy is now becoming a promising strategy for expanding the organ donor pool. <jats:italic>Methods<\/jats:italic>. This retrospective, comparative, single\u2010center study included HCV viremic donor kidneys that were transplanted to 9 HCV\u2010positive (HCV Ab\u2010positive) recipients (D+\/R+ group) and 14 HCV\u2010negative recipients (D+\/R\u2010 group) from May 2018 to January 2021. Both groups received prophylaxis with SOF\/VEL treatment within 1\u2010week posttransplant devoid of HCV genotyping\/subtyping. The primary outcomes were sustained virologic response 12 weeks after completion of therapy (SVR12) and graft survival at 1\u2010year posttransplant. <jats:italic>Results<\/jats:italic>. Baseline characteristics were similar between the HCV D+\/R\u2010 and D+\/R+ groups. The mean age of all recipients was 39.09 \u00b1 9.65 (SD) years, and 73.9% were male. A total of 92.9% (13 out of 14) recipients had pretreatment HCV viremia in the D+\/R\u2010 group. The pretreatment HCV viral load in the D+\/R+ group (5.98, log 10\u2009IU\/mL; IQR, 5.28\u20106.53) was significantly higher than that in the D+\/R\u2010 group (3.61, log 10\u2009IU\/mL; IQR, 2.57\u20104.57). After SOF\/VEL treatment, SVR12 was achieved in all recipients, with a 100% 1\u2010year patient and graft survival rates. The D+\/R+ group had a higher incidence of abnormal liver function (44.4% vs. 7.1%). No significant difference was observed between the two groups in terms of DGF, acute rejection, ALT, serum creatinine, and eGFR within 1\u2010year posttransplant. No severe adverse events associated with either HCV viremia or SOF\/VEL were observed. <jats:italic>Conclusions<\/jats:italic>. Using a simplified genotyping\/subtyping\u2010free SOF\/VEL treatment strategy, kidneys from hepatitis C viremic donors for both infected and uninfected recipients presented with safe, excellent, and comparable 1\u2010year outcomes, which can safely expand the donor pool. HCV\u2010positive donor kidneys should be utilized regularly, regardless of the recipient\u2019s HCV status.<\/jats:p>","DOI":"10.1155\/2022\/3758744","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T21:20:07Z","timestamp":1659216007000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Utilization of HCV Viremic Kidneys with Genotyping\/Subtyping\u2010Free Sofosbuvir\/Velpatasvir Treatment Strategy: Experience from 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