{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T17:17:47Z","timestamp":1776705467207,"version":"3.51.2"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Case Reports in Medicine"],"published-print":{"date-parts":[[2022,9,28]]},"abstract":"<jats:p>Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious condition which usually develops 4 to 6 weeks after SARS-CoV-2 infection in a genetically predisposed individual. Clinical features are heterogeneous and include fever, respiratory compromise, mucocutaneous involvement with conjunctival abnormalities and erythematous exanthem, abdominal pain, and diarrhea. Neurologic and cardiovascular symptoms can also develop, including coronary artery dilatation. Some cases involve 2 or more organs and require critical admission. Echocardiography is the mainstay of cardiac evaluation in the acute setting as well as on outpatient follow-up. We present the case of a 4-month-old female with no past medical or surgical history who presented with a prolonged febrile syndrome associated with severe respiratory illness, gastrointestinal symptoms, and mucocutaneous abnormalities. Diagnosis of MIS-C was established based on clinical findings, persistently elevated markers of systemic inflammation and positive SARS-CoV-2 molecular test and evidence of prior SARS-CoV-2 infection with SARS-CoV-2 IgG positive. Echocardiogram evidenced myopericarditis and coronary aneurysms and patient was deemed candidate for immunomodulatory therapy with intravenous immunoglobulin (IVIg), resulting in favorable clinical and paraclinical outcomes. Few cases of giant coronary aneurysms have been reported in children. There are no existing literature reports about coronary thrombosis or thrombus formation resulting from vascular aneurysmal dilations in this population. As such, the prognosis and natural history of coronary artery aneurysms in the setting of MIS-C remain largely unknown.<\/jats:p>","DOI":"10.1155\/2022\/3785103","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T21:35:09Z","timestamp":1664400909000},"page":"1-5","source":"Crossref","is-referenced-by-count":2,"title":["Giant Partially Thrombosed Coronary Aneurysm in Multisystem Inflammatory Syndrome Associated with SARS-CoV-2 in Children"],"prefix":"10.1155","volume":"2022","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5930-8590","authenticated-orcid":true,"given":"Karen Daniela","family":"Manchola Narv\u00e1ez","sequence":"first","affiliation":[{"name":"Pediatric Resident, Surcolombiana University, Hospital Universitario de Neiva, Neiva Huila, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5041-387X","authenticated-orcid":true,"given":"Natalia del Pilar Delgado","family":"Ort\u00edz","sequence":"additional","affiliation":[{"name":"Pediatric Resident, Surcolombiana University, Hospital Universitario de Neiva, Neiva Huila, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8230-5478","authenticated-orcid":true,"given":"Iv\u00e1n Jos\u00e9","family":"Ardila G\u00f3mez","sequence":"additional","affiliation":[{"name":"Ivan Jose Ardila Gomez, Pediatric Critical Care, Cl\u00ednica Uros, Hospital Universitario de Neiva, Surcolombiana University, Neiva-Huila, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4756-6808","authenticated-orcid":true,"given":"Pilar P\u00e9rez","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pilar P\u00e9rez L\u00f3pez, Pediatric Rheumatologist, Cl\u00ednica Uros, Cl\u00ednica Medilaser, Hospital Universitario de Neiva, Surcolombiana University, Neiva-Huila, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mart\u00edn Fernando","family":"Rivera Ort\u00edz","sequence":"additional","affiliation":[{"name":"Pediatric Cradiologist, Pediatric Congenital Cardiac Sonographer, Hospital Universitario de Neiva, Neiva, Surcolombiana University, Neiva, Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","reference":[{"key":"1","first-page":"11","article-title":"Multisystem inflammatory syndrome in children (mis-c), a post-viral myocarditis and systemic vasculitis-a critical review of its pathogenesis and treatment","volume":"8","author":"J. C. Mcmurray","year":"2020","journal-title":"Frontires in Pediatrics"},{"key":"2","article-title":"Cardiac manifestations in SARS-CoV-2-associated multisystem inflammatory syndrome in children: a comprehensive review and proposed clinical approach","volume":"180","author":"F. Sperotto","year":"2020","journal-title":"Europian Journal of Pediatrics"},{"key":"3","doi-asserted-by":"publisher","DOI":"10.1007\/s12519-021-00435-y"},{"key":"4","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.01.054"},{"key":"5","article-title":"Review of cardiac involvement in multisystem inflammatory syndrome in children","volume":"143","author":"T. 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